Adrenal Ganglioneuroma Presenting As Left Renal Mass

Abstract

Ganglioneuromas (GNs) are benign tumors resulting from neural crest tissue. GNs contain mature ganglion cells and Schwann cells. GNs most commonly occur in the retroperitoneum and posterior mediastinum. GNs rarely occur in the adrenal gland. A 45-year-old asymptomatic patient presented with an incidental finding of left renal mass. A 10 cm mass lesion located in the upper pole of the left kidney and lymphadenopathy in renal hilus were detected. The patient underwent transperitoneal radical nephrectomy involving the removal of left adrenal gland. The immunohistochemical examination showed strong positive staining for S100, neuron-specific enolase, synaptophysin and chromogranin. The diagnosis of mature GN was established. GNs are among the rare diseases that should be considered in the evaluation of renal masses, particularly in the differential diagnosis of upper pole tumors of the kidneys. It can be confused with renal cell carcinomas.




World J Oncol. 2014;5(2):90-92
doi: http://dx.doi.org/10.14740/wjon783w