World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Original Article

Volume 9, Number 3, June 2018, pages 69-73


Failure of Ploidy and Proliferative Fraction to Predict Long-Term Outcome After Prostatectomy

Tables

Table 1. Patient Characteristics
 
NumberMeanMedRange
LN: lymph nodes; SV: seminal vesicles; EPE: extraprostatic extension; Mar: margins.
Age at surgery12766 yrs67 yrs47 - 83
Preoperative PSA12110.4 ng/mL10.3 ng/mL1.4 - 54.6
S phase1068.2%6.6%0.8 - 33.0
Gleason
  < 759
  759
  > 79
Ploidy
Diploid107
Aneuploid20
Pathology findings
  LN+10
  SV+21
  EPE+38
  Mar+30

 

Table 2. Association of Ploidy and S Phase With Gleason Score and PSA
 
Gleason < 7 (%)Gleason 7 (%)Gleason > 7 (%)P valuePSA < 10 (%)PSA > 10 (%)P value
P-value was calculated by Mantel-Haenszel Chi-square test. £P-value was calculated by Fisher’ exact Chi-square test. ±P-value was calculated by Pearson Chi-square test.
Diploid51 (48%)47 (44%)9 (8%)0.34878 (73%)29 (27%)0.472£
Non-diploid8 (40%)12 (60%)013 (65%)7 (35%)
S phase < 6.6%37 (50%)31(42%)6 (8%)0.48352 (70%)22 (30%)0.682±
S phase > 6.6%22 (42%)28 (53%)3 (6%)39 (74%)14 (26%)

 

Table 3. Biochemical Failure Based on Each Factor
 
Biochemical failure£PC death
FactorNumberFailed #Failed %P-valueP-value
£P-values were calculated by Pearson Chi-square test or Mantel-Haenszel Chi-square test. When at least one cell that expected count less than 5, Fisher’s exact test was implemented. PC death is the death caused by prostate cancer. P values were calculated with the use of Cox proportional-hazards models.
Diploid1075148%0.82660.1709
Non diploid20945%
S phase ≤ 6.6%743041%0.07380.8400
S phase > 6.6%533057%
EPE+382874%< 0.00010.0749
EPE-883135%
Mar+302170%0.00360.3868
Mar-963840%
SV+211571%0.01670.2033
SV-1054442%
LN+10990%0.00630.6428
LN-1175144%
Gleason < 7591932%0.00080.0023
Gleason 7593356%
Gleason > 79889%
PSA < 10913437%0.00040.5478
PSA > 10362672%