World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Case Report

Volume 6, Number 2, April 2015, pages 345-348

Denosumab Therapy for Refractory Hypercalcemia Secondary to Squamous Cell Carcinoma of Skin in Epidermolysis Bullosa

Figures

Figure 1.
Figure 1. Initial management of hypercalcemia (week 1 and week 2). HH denotes hyperhydration.
Figure 2.
Figure 2. Response to denosumab (60 mg subcutaneous injection).

Table

Table 1. Serum Concentrations of Various Parameters at Presentation
 
Corrected calcium (mmol/L)4.2 (2.25 - 2.74)
Phosphate (mmol/L)0.83 (0.74 - 1.53)
Alkaline phosphatase (IU/L)2,500 (203 - 1,151)
Parathyroid hormone (pmol/L)0.7 (1.1 - 6.9)
25 Hydroxy vitamin D (nmol/L)31 (> 50)
PTHrP (pmol/L)2.1 (0.0 - 1.8)
1,25 Hydroxy vitamin D (pmol/L)173 (43 - 143)