World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Review

Volume 8, Number 3, June 2017, pages 63-70

The Effects of Anesthetics on Recurrence and Metastasis of Cancer, and Clinical Implications

Table

Table 1. The Recent Studies on the Effect of Anesthetics on Cancers [4-17]
 
Type of anestheticsAnestheticsAuthorsYearType of cancer (n)Type of researchEffect on cancerRelative pathway
↑: enhance cancer; ↓: inhibit cancer grow or metastasis; -: no effect on cancer.
Intravenous anestheticsPropofolXu et al [9]2016OsteosarcomaIn vitro↓TGF-beta1
PropofolLiu et al [10]2016Pancreatic cancerIn vivo↓miR-21
Propofol, etomidate, dexmedetomidineDeng et al [8]2016Colorectal cancerIn vivo and in vitroPropofol: ↓ in vitro, - in vivo
Etomidate: ↑
Dexmedetomidine: -		(PI3K)/AKT, epithelial-mesenchymal transition.
PropofolXu et al [9]2016GlioblastomaIn vitro↓miR-218
Mu agonistsWang et al [13]2015Non small cell lung cancerRetrospective study↑No
Local anestheticsLidocaineXing et al [15]2017Hepatocellular carcinomaIn vitro↓Bax protein caspase-3, Bcl-2 protein
BupivacaineXuan et al [17]2016Ovarian and prostate cancerIn vitro↓glycogen synthase kinase-3β
Lidocaine, ropivacaineWang et al [16]2016Non-small cell lung cancerIn vitroLidocaine ↓
Ropivacaine ↓		mitogen-activated protein kinase (MAPK) pathways
ProcaineMa et al [12]2016Non-small cell lung cancerIn vivo and in vitro↓mRNA expression of the key NSCLC target EGFR
Lidocaine, ropivacainePiegeler et al [14]2015Lung adenocarcinomaIn vitro↓MMP-9, Src-dependent inflammatory signalling events
Volatile anestheticsDesflurane, isofluraneCata et al [11]2017GlioblastomaMETA analysis-No
Isoflurane, sevoflurane, desfluraneIwasaki et al [4]2016Ovarian carcinomaIn vitro↑MMP11 and VEGF-A
Sevoflurane, thiopentalHurmath et al [6]2016GlioblastomaIn vitro↓Matrix metalloproteinases
IsofluraneZhu et al [5]2016GlioblastomaIn vitro↑No
DesfluraneElias et al [7]2015Ovarian cancerRetrospective study↓No