World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Case Report

Volume 8, Number 3, June 2017, pages 81-85

Rare Presentation of Adrenocortical Carcinoma in a 4-Month-Old Boy

Figures

Figure 1.
Figure 1. A 4-month-old male infant with an adrenocortical carcinoma at the time of presentation (a) and the same boy (b) at 7 years of age.
Figure 2.
Figure 2. CT scan reports 6.8 × 7.7 cm size mass at the upper pole of left kidney.
Figure 3.
Figure 3. Histology of a high grade adrenocortical carcinoma in a 4-month-old male. (a) The tumor cells have large nuclei and prominent nucleoli. Furthermore, prominent mitotic figures are seen. (b) Confluent areas of necrosis are visualized. (c) Tumor cells show positive reaction for synaptophysin. (d) Tumor cells have positive reaction for melan-A.
Figure 4.
Figure 4. Growth chart demonstrating linear growth deceleration at diagnosis, followed by normal linear growth after surgical resection.

Table

Table 1. A Summary of All Case Reports of Pediatric ACC Along With Their Age at Diagnosis, Sex and Presenting Features That Were Found on PubMed
 
AuthorAge at diagnosisSexPresentation
Fudge et al [4]6 monthsFIsolated Cushing’s
Garge et al [5]3 monthsMIsolated Cushing’s
De Leon et al [6]2 monthsMIsolated Cushing’s
Romaguera et al [7]4 yearsFCushingoid features, virilization
Kanmaz et al [8]4 yearsFAbdominal pain, non-functional tumor
Breidbart et al [9]3 years and 5 monthsFVirilization
Kim et al [10]8 years and 2 monthsMVirilization, peripheral precocious puberty
Arico et al [11]2 yearsFVirilization
Wong et al [12]12 yearsFSecondary amenorrhea, virilization, Cushing’s syndrome
Sorgo et al [13]12 years and 10 monthsFVirilization
Ghazizadeh et al [14]2 yearsFVirilization, heterosexual pseudoprecocious puberty