World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 8, Number 6, December 2017, pages 175-179

Combination of Advanced Lung Cancer Inflammation Index and C-Reactive Protein Is a Prognostic Factor in Patients With Operable Non-Small Cell Lung Cancer

Figure 2. Overall postoperative cancer specific survival of patients based on the combination of ALI and CRP (a) and the ALI_CRP score (b).

**Table 1.** Clinical Characteristics of Patients Based on the ALI_CRP Score
	ALI_CRP score 0	ALI_CRP score 1	ALI_CRP score 2	P value
ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.
Age
< 65	57	39	10	0.138
≥ 65	116	78	41
Gender
Male	71	63	39	< 0.001
Female	102	54	12
Smoking status
Current/former	73	68	42	< 0.001
Never	100	49	9
Histology
Adenocarcinoma	153	86	29	< 0.001
Others	20	31	22
pStage
I	144	89	32	0.010
II-III	29	28	19
pT status
pT1	126	83	26	0.014
pT2-3	47	34	25
pN status
pN0	154	99	39	0.089
pN1-2	19	18	12
CEA
Normal	133	84	37	0.586
High	40	33	14
CYFRA21-1
Normal	156	91	36	0.001
High	17	26	15

Table 1. Clinical Characteristics of Patients Based on the ALI_CRP Score

ALI_CRP score 0

ALI_CRP score 1

ALI_CRP score 2

P value

ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.

Age

< 65

0.138

≥ 65

116

Gender

Male

< 0.001

Female

102

Smoking status

Current/former

< 0.001

Never

100

Histology

Adenocarcinoma

153

< 0.001

Others

pStage

144

0.010

II-III

pT status

pT1

126

0.014

pT2-3

pN status

pN0

154

0.089

pN1-2

CEA

Normal

133

0.586

High

CYFRA21-1

Normal

156

0.001

High

**Table 2.** Univariate Analysis
	Favorable	Unfavorable	Hazard ratio	P value	95% confidence interval
ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.
Age	< 65	≥ 65	0.757	0.240	0.462	1.196
Gender	Female	Male	0.328	< 0.001	0.203	0.513
Smoking status	Never	Current/former	0.349	< 0.001	0.215	0.548
Histology	Adenocarcinoma	Others	0.249	< 0.001	0.164	0.380
pT status	pT1	pT2-3	0.451	< 0.001	0.299	0.685
pN status	pN0	pN1-2	0.332	< 0.001	0.212	0.536
CEA	Normal	High	0.380	< 0.001	0.251	0.584
CYFRA21-1	Normal	High	0.352	< 0.001	0.229	0.555
ALI_CRP score	Score 0	Others	0.287	< 0.001	0.177	0.451

Table 2. Univariate Analysis

Favorable

Unfavorable

Hazard ratio

P value

95% confidence interval

Lower

Upper

ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.

Age

< 65

≥ 65

0.757

0.240

0.462

1.196

Gender

Female

Male

0.328

< 0.001

0.203

0.513

Smoking status

Never

Current/former

0.349

< 0.001

0.215

0.548

Histology

Adenocarcinoma

Others

0.249

< 0.001

0.164

0.380

pT status

pT1

pT2-3

0.451

< 0.001

0.299

0.685

pN status

pN0

pN1-2

0.332

< 0.001

0.212

0.536

CEA

Normal

High

0.380

< 0.001

0.251

0.584

CYFRA21-1

Normal

High

0.352

< 0.001

0.229

0.555

ALI_CRP score

Score 0

Others

0.287

< 0.001

0.177

0.451

**Table 3.** Multivariate Analysis
	Favorable	Unfavorable	Hazard ratio	P value	95% confidence interval
ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.
Gender	Female	Male	0.371	0.003	0.185	0.721
Smoking status	Never	Current/former	0.730	0.384	0.365	1.492
Histology	Adenocarcinoma	Others	0.448	0.001	0.277	0.728
pT status	pT1	pT2-3	0.958	0.861	0.595	1.561
pN status	pN0	pN1-2	0.392	0.001	0.235	0.669
CEA	Normal	High	0.443	0.001	0.285	0.698
CYFRA21-1	Normal	High	0.772	0.319	0.472	1.291
ALI_CRP score	Score 0	Others	0.379	< 0.001	0.227	0.612

Table 3. Multivariate Analysis

Favorable

Unfavorable

Hazard ratio

P value

95% confidence interval

Lower

Upper

ALI: advanced lung cancer inflammation index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments.

Gender

Female

Male

0.371

0.003

0.185

0.721

Smoking status

Never

Current/former

0.730

0.384

0.365

1.492

Histology

Adenocarcinoma

Others

0.448

0.001

0.277

0.728

pT status

pT1

pT2-3

0.958

0.861

0.595

1.561

pN status

pN0

pN1-2

0.392

0.001

0.235

0.669

CEA

Normal

High

0.443

0.001

0.285

0.698

CYFRA21-1

Normal

High

0.772

0.319

0.472

1.291

ALI_CRP score

Score 0

Others

0.379

< 0.001

0.227

0.612