World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
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Volume 9, Number 1, February 2018, pages 1-4

Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports


Table 1. Patients Demographics, Associated Malignancy, Clinical Presentation and Outcome [6-11]
Case reportsPatientAge/sexDiagnosisOther immnuno-therapyChemotherapyPresentationHBA1CNumber of dosesAntibodyOutcome
GAD: glutamic acid decarboxylase.
Malik et al [6]155/MMelanomaIpilimumabDacarbazineDKA10.70%9 cyclesNegativeOn insulin
Gaudy et al [7]244/FMelanomaIpilimumabNot statedDKA6.85%2 cyclesNegativeOn insulin
Hughes et al [8]364/FMelanomaNoneNoneDKA7.40%Not knownNegativeNot known
Chae et al [9]476/MNSCLCNoneCarboplatin and paclitaxelDM5.80%2 cyclesPositive anti-GADOn insulin
Hansen et al [10]558/MMelanomaIpilimumabNoneDM9.70%17 cyclesPositive anti-GADOn insulin
Juan et al [11]654/FMelanomaIpilimumabNoneDKAN/A3 cyclesPositive anti-GADOn insulin