World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Original Article

Volume 9, Number 3, June 2018, pages 91-95


Comparison of Single Versus Multifraction Radiotherapy in Palliation of Painful Bone Metastases

Tables

Table 1. Patient Characteristics
 
CharacteristicsGroup I (n = 20)Group II (n = 20)Group III (n = 20)
Mean age/range (years)58.6/ 45 - 7560.5/35 - 8256.5/37 - 74
Number of patientsPercentageNumber of patientsPercentageNumber of patientsPercentage
GenderMale147013651575
Female630735525
Rural/urban statusRural147013651470
Urban630735630
Karnofsky performance status ≥ 60147012601260
Site of primaryProstate1050735420
Breast52531515
Lung31515525
MUO15210840
Others15735210
Site of bone metastasesMultiple840735315
Spine6308401050
Pelvis315420315
Sternum1515420
Axial skeleton2100000
Site of palliative radiotherapySpine8409451050
Pelvis840840525
Others420315525

 

Table 2. Post-Treatment Observations
 
Group I (n = 20)Group II (n = 20)Group III (n = 20)
Number of patientsPercentageNumber of patientsPercentageNumber of patientsPercentage
Complete pain response420420420
Overall pain response168015751785
Minimum mean pain score31.5-37.8-31.6-
Improved performance status210420210
Decreased analgesic requirement136513651365
Mean duration of pain relief23.5weeks-22.6 weeks-21.9 weeks-
Re-irradiation4201500

 

Table 3. Assessment of Economic Impact in the Multifraction Regimens
 
Group IGroup IIGroup III
Average distance travelled per day for radiation treatment (i.e. from home to treatment center and back)101 km102.4 km97 km
Number of radiation treatment days1510
Average distance travelled from home to treatment center for complete radiation treatment101 km512 km970 km
Total expenditure on travel during radiation treatment considering average cost of travel at Rs 10/kmRs 1,010
per patient
Rs 5,120
per patient
Rs 9,700
per patient

 

Table 4. Randomized Trials Comparing Single versus Multifraction Radiotherapy in Bone Metastases
 
StudyComplete pain reliefOverall pain reliefRetreatment
Bone Trial Working Party Study Group (1999) [14]8 Gy single fraction57%78%23%
20 Gy/5 Fr or
30 Gy/10 Fr
58%78%10%
Hartsell et al (2005) [17]8 Gy single fraction15%65%18%
30 Gy/10 Fr18%66%9%
Roos et al (2005) [18]8 Gy single fraction26%53%1%
20 Gy/5 Fr27%61%0
Arnalot et al (2008) [19]8 Gy single fraction15%75%28%
30 Gy/10 Fr13%86%2%
Anter et al (2015) [20]8 Gy single fraction18%75%-
20 Gy/5 Fr22%75%-