World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Original Article

Volume 9, Number 5-6, November 2018, pages 151-155

EGFR Mutation Detection and Its Association With Clinicopathological Characters of Lung Cancer Patients

Figures

Figure 1.
Figure 1. (a, b) Showing positive and negative EGFR mutation of E746-A750 in exon 19, and (c, d) showing positive and negative EGFR mutation of L858R mutation in exon 21.
Figure 2.
Figure 2. Showing the NSCLC patients having positive EGFR mutations of exon 21 (L858R) and exon 19 (E746-A750).

Tables

Table 1. Demographic and Clinical Profile of Lung Cancer Patients
 
ParameterLung cancer (N = 70)
Age (years)53.67 ± 11.29
Sex
  Male52 (74.29%)
  Females18 (25.71%)
Height157.28 ± 7.71
Weight46.84 ± 9.98
BMI18.84 ± 3.34
Smoking history
  Smokers7 (10%)
  Ex-smokers24 (34%)
  Non-smokers39 (55%)
Clinical staging
  I/II1 (1.43%)
  III/IV69 (98.57%)
Clinical symptoms
  Cough58 (89.23%)
  Chest pain53 (81.54%)
  Breathlessness53 (81.54%)
  Fever37 (56.92%)
  Hemoptysis22 (33.86%)
  Loss of appetite43 (66.15%)
  Change in voice8 (12.31%)
  Vomiting6 (9.23%)

 

Table 2. Clinical Characteristics of Lung Cancer Patients Having Positive and Negative EGFR Mutations
 
ParametersMutation positive (N = 24)Mutation negative (N = 46)P value
Age55.58 ± 9.3953.67 ± 10.930.4647
Sex
  Male15 (62.5%)37 (80.43%)0.614
  Females9 (37.5%)9 (19.57%)
Religion
  Hindu23 (95.83%)41 (89.13%)0.654
  Muslim1 (4.17%)5 (10.87%)
Smoking history
  Smokers2 (8.33%)5 (10.87%)< 0.05
  Ex-smokers4 (16.67%)20 (43.48%)
  Non-smokers18 (75%)21 (45.65%)
Clinical staging
  I/II0 (0%)1 (2.17%)0.4578
  III/IV24 (100%)45 (97.83%)

 

Table 3. Relationship Between the Type of EGFR Mutation and Clinicopathological Characters of Lung Cancer Patients
 
Parameters(L858R) exon 21 mutation (N = 5)(E746-A750) exon 19 mutation (N = 19)P value
Gender
  Male4 (80%)11 (57.9%)0.614
  Female1 (20%)8 (42.1%)
Smoking
  Smoker1 (20%)1 (5.3%)0.127
  Ex-smokers2 (40%)2 (10.5%)
  Non-smoker2 (40%)16 (84.2%)