World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 10, Number 4-5, October 2019, pages 176-180

The Prognostic Values of a Novel Preoperative Inflammation-Based Score in Japanese Patients With Non-Small Cell Lung Cancer

**Table 1.** Summary of the Inflammation-Based Indexes
	Neut	Lym	PLT	ALB	CRP	BMI
Neut: neutrophil count; Lym: lymphocyte count; PLT: platelet count; ALB: serum albumin; CRP: C-reactive protein; BMI: body mass index.
Glasgow prognostic score (GPS)				○	○
Neutrophil/lymphocyte ratio (NLR)	○	○
Platelet/lymphocyte ratio (PLR)		○	○
Prognostic nutritional index (PNI)		○		○
Systemic immune-inflammation index (SII)	○	○	○
Advance lung cancer inflammation index (ALI)	○	○		○		○
Inflammatory prognostic index (IPI)	○	○		○	○

Table 1. Summary of the Inflammation-Based Indexes

Neut

Lym

PLT

ALB

CRP

BMI

Neut: neutrophil count; Lym: lymphocyte count; PLT: platelet count; ALB: serum albumin; CRP: C-reactive protein; BMI: body mass index.

Glasgow prognostic score (GPS)

○

Neutrophil/lymphocyte ratio (NLR)

○

Platelet/lymphocyte ratio (PLR)

○

Prognostic nutritional index (PNI)

○

Systemic immune-inflammation index (SII)

○

Advance lung cancer inflammation index (ALI)

○

Inflammatory prognostic index (IPI)

○

**Table 2.** Clinicopathological Characteristics of Patients
	No. of patients
CEA: carcinoembryonic antigen; ALB: serum albumin; NLR: neutrophil to lymphocyte ratio; CRP: C-reactive protein; BMI: body mass index; PLT: platelet to lymphocyte ratio.
Age	128
< 65	272
≥ 65
Gender	211
Male	189
Female
Smoking status	223
Current/former	177
Never
Histology	315
Adenocarcinoma	85
Others
pStage	307
I	93
II-III
pT status	266
pT1	134
pT2-3
pN status	339
pN0	61
pN1-2
CEA	292
Normal	108
High
ALB	99
Low	301
Normal
NLR	257
Low	143
High
CRP	276
Normal	124
High
BMI	138
Low	262
High
PLR	268
Low	132
High

Table 2. Clinicopathological Characteristics of Patients

No. of patients

CEA: carcinoembryonic antigen; ALB: serum albumin; NLR: neutrophil to lymphocyte ratio; CRP: C-reactive protein; BMI: body mass index; PLT: platelet to lymphocyte ratio.

Age

128

< 65

272

≥ 65

Gender

211

Male

189

Female

Smoking status

223

Current/former

177

Never

Histology

315

Adenocarcinoma

Others

pStage

307

II-III

pT status

266

pT1

134

pT2-3

pN status

339

pN0

pN1-2

CEA

292

Normal

108

High

ALB

Low

301

Normal

NLR

257

Low

143

High

CRP

276

Normal

124

High

BMI

138

Low

262

High

PLR

268

Low

132

High

**Table 3.** Univariate and Multivariate Analyses of Inflammation Markers
Factor	Univariate	Multivariate
CI: confidence interval; ALB: serum albumin; NLR: neutrophil to lymphocyte ratio; CRP: C-reactive protein; BMI: body mass index; PLT: platelet to lymphocyte ratio.
ALB	1.797	0.003	1.223	2.602	1.462	0.060	0.983	2.144
NLR	2.284	0.019	1.158	4.053	1.547	0.217	0.758	2.889
CRP	2.249	< 0.001	1.566	3.218	1.910	0.001	1.306	2.778
BMI	1.933	< 0.001	1.348	2.766	1.720	0.004	1.191	2.477
PLT	1.726	0.004	1.198	2.473	1.346	0.143	0.903	1.982

Table 3. Univariate and Multivariate Analyses of Inflammation Markers

Factor

Univariate

Multivariate

Risk ratio

P value

95% CI

Risk ratio

P value

95% CI

Lower

Upper

Lower

Upper

CI: confidence interval; ALB: serum albumin; NLR: neutrophil to lymphocyte ratio; CRP: C-reactive protein; BMI: body mass index; PLT: platelet to lymphocyte ratio.

ALB

1.797

0.003

1.223

2.602

1.462

0.060

0.983

2.144

NLR

2.284

0.019

1.158

4.053

1.547

0.217

0.758

2.889

CRP

2.249

< 0.001

1.566

3.218

1.910

0.001

1.306

2.778

BMI

1.933

< 0.001

1.348

2.766

1.720

0.004

1.191

2.477

PLT

1.726

0.004

1.198

2.473

1.346

0.143

0.903

1.982

**Table 4.** Univariate and Multivariate Analyses
Factor	Univariate	Multivariate
CI: confidence interval; CEA: carcinoembryonic antigen.
Age	1.208	0.346	0.820	1.820
Gender	3.470	< 0.001	2.314	5.362	2.568	0.001	1.437	4.716
Smoking status	3.358	< 0.001	2.220	5.255	1.075	0.820	0.583	2.029
Histology	3.522	< 0.001	2.427	5.067	2.100	< 0.001	1.405	3.125
pT status	2.212	< 0.001	1.543	3.166	1.110	0.615	0.736	1.665
pN status	2.616	< 0.001	1.718	3.882	2.069	0.003	1.289	3.270
CEA	2.243	< 0.001	1.545	3.226	1.870	0.002	1.273	2.723
Novel score	2.802	< 0.001	1.884	4.282	2.025	0.001	1.343	3.132

Table 4. Univariate and Multivariate Analyses

Factor

Univariate

Multivariate

Risk ratio

P value

95% CI

Risk ratio

P value

95% CI

Lower

Upper

Lower

Upper

CI: confidence interval; CEA: carcinoembryonic antigen.

Age

1.208

0.346

0.820

1.820

Gender

3.470

< 0.001

2.314

5.362

2.568

0.001

1.437

4.716

Smoking status

3.358

< 0.001

2.220

5.255

1.075

0.820

0.583

2.029

Histology

3.522

< 0.001

2.427

5.067

2.100

< 0.001

1.405

3.125

pT status

2.212

< 0.001

1.543

3.166

1.110

0.615

0.736

1.665

pN status

2.616

< 0.001

1.718

3.882

2.069

0.003

1.289

3.270

CEA

2.243

< 0.001

1.545

3.226

1.870

0.002

1.273

2.723

Novel score

2.802

< 0.001

1.884

4.282

2.025

0.001

1.343

3.132