Figure 1. Colonic tissue with features of graft-versus-host disease. Histologic section of a colonic biopsy shows extensive crypt cell apoptosis, crypt destruction and dropout with focal mucosal necrosis and epithelial denudation. Black arrows indicate most prominent single-cell crypt apoptosis (hematoxylin-eosin, original magnification, × 200).
Figure 2. Liver tissue with features of graft-versus-host disease. Histologic section of a core liver biopsy shows mixed portal inflammatory infiltrates composed of neutrophils, lymphocytes and occasional plasma cells. There is extensive bile duct injury and interface hepatitis. Black arrows indicate damaged bile ducts (hematoxylin-eosin, original magnification, × 200).