World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website https://www.wjon.org

Original Article

Volume 12, Number 4, August 2021, pages 93-103

Breast Cancer in Jamaica: Stage, Grade and Molecular Subtype Distributions Across Age Blocks, the Implications for Screening and Treatment

Figure 1. Pie chart representing the distribution of new breast cancers in percentages between invasive and ductal carcinoma in situ (DCIS) in the KPH-R over 14-month period under study and USA using the SEER database (2012 - 2015). SEER: Surveillance Epidemiology and End Result; KPH-R: Kingston Public Hospital Breast Cancer Registry.

Figure 2. Bar chart depicting the distribution of new breast cancers (in percentages) by cancer subtype for patients. Overall < 50 years, 50 - 59 years, > 59 years in the KPH-R over the 14-month period under study. KPH-R: Kingston Public Hospital Breast Cancer Registry.

Figure 3. Pie chart depicting distribution of new invasive breast cancers (in percentages) by cancer subtype in the American Cancer Society database 2012 - 2016.

Figure 4. Pie chart depicting the distribution of new invasive breast cancers (in percentages) by cancer subtype in the SEER database 2012 - 2015. SEER: Surveillance Epidemiology and End Result.

Figure 5. Pie chart depicting distribution of new breast cancers in non-Hispanic Blacks by cancer subtype in the SEER database 2012 - 2015. SEER: Surveillance Epidemiology and End Result.

Figure 6. Bar chart depicting the age distributions of new breast cancers (in percentages) in KPH-R over the 14-month period under study and the SEER database 2012 - 2015. SEER: Surveillance Epidemiology and End Result; KPH-R: Kingston Public Hospital Breast Cancer Registry.

**Table 1.** Distribution of the Grades of New Breast Cancers in the SEER Database (2012 - 2015) and KPH-R (2017 - 2018)
Grade	SEER overall, N (%)	SEER NHB, N (%)	KPH-R overall, N (%)	KPH-R < 50 years, N (%)	KPH-R 50 - 59 years, N (%)	KPH-R > 59 years, N (%)
The overall grades are reported for the SEER, SEER NHB and KPH-R along with grades across age groups in the KPH-R. NHB denotes African American patients. SEER: Surveillance Epidemiology and End Result; KPH-R: Kingston Public Hospital Breast Cancer Registry; NHB: non-Hispanic Black.
Low	242,660 (21)	17,857 (13)	8 (8)	0	4 (11)	4 (15)
Moderate	482,695 (41)	46,398 (35)	44 (44)	18 (51)	13 (35)	13 (48)
High	340,430 (29)	55,714 (42)	39 (39)	15 (43)	16 (43)	8 (30)
Unknown	108,561 (9)	14,018 (10)	8 (8)	2 (6)	4 (11)	2 (7)
Total	1,174,346 (100)	133,987 (100)	99 (100)	105 (100)	100 (100)	100 (100)

Table 1. Distribution of the Grades of New Breast Cancers in the SEER Database (2012 - 2015) and KPH-R (2017 - 2018)

Grade

SEER overall, N (%)

SEER NHB, N (%)

KPH-R overall, N (%)

KPH-R < 50 years, N (%)

KPH-R 50 - 59 years, N (%)

KPH-R > 59 years, N (%)

The overall grades are reported for the SEER, SEER NHB and KPH-R along with grades across age groups in the KPH-R. NHB denotes African American patients. SEER: Surveillance Epidemiology and End Result; KPH-R: Kingston Public Hospital Breast Cancer Registry; NHB: non-Hispanic Black.

Low

242,660 (21)

17,857 (13)

8 (8)

4 (11)

4 (15)

Moderate

482,695 (41)

46,398 (35)

44 (44)

18 (51)

13 (35)

13 (48)

High

340,430 (29)

55,714 (42)

39 (39)

15 (43)

16 (43)

8 (30)

Unknown

108,561 (9)

14,018 (10)

8 (8)

2 (6)

4 (11)

2 (7)

Total

1,174,346 (100)

133,987 (100)

99 (100)

105 (100)

100 (100)

**Table 2.** Distribution of Patients With Stage III Invasive Breast Cancer With High Histological Grade Across Age Groups in KPH-R
	< 50 years	50 - 59 years	> 59 years	P value
KPH-R: Kingston Public Hospital Breast Cancer Registry.
Stage III with grade 3, N (%)	11 (65)	3 (18)	3 (18)	0.033

Table 2. Distribution of Patients With Stage III Invasive Breast Cancer With High Histological Grade Across Age Groups in KPH-R

< 50 years

50 - 59 years

> 59 years

P value

KPH-R: Kingston Public Hospital Breast Cancer Registry.

Stage III with grade 3, N (%)

11 (65)

3 (18)

0.033

**Table 3.** Distribution of Grade, Molecular Subtype, Tumor Size, Nodal Status and Stage Across Age Groups in the KPH-R
Characteristics	Overall	Age < 50 years, N (%)	Age 50 - 59 years, N (%)	Age > 59 years, N (%)	P value (Chi-square)
KPH-R: Kingston Public Hospital Breast Cancer Registry.
Grade 1	8 (8)	0 (0)	4 (11)	4 (15)	0.119
Grade 2	44 (44)	18 (51)	13 (35)	13 (48)
Grade 3	39 (39)	15 (43)	16 (43)	8 (30)
Unknown	8 (8)	2 (6)	4 (11)	2 (7)
Total	99 (100)	35 (100)	37 (100)	27 (100)
Luminal A	48 (48)	14 (40)	19 (51)	15 (56)	0.777
Luminal B	10 (10)	3 (9)	5 (14)	2 (7)
HER2 enriched	7 (7)	4 (11)	1 (3)	2 (7)
Triple negative	21 (21)	7 (20)	9 (24)	5 (19)
Unknown	13 (13)	7 (20)	3 (8)	3 (11)
T1	10 (10)	2 (6)	7 (19)	1 (4)	0.157
T2	36 (36)	13 (37)	13 (35)	10 (37)
T3	22 (22)	9 (26)	8 (22)	5 (19)
T4	21 (21)	10 (29)	3 (8)	8 (30)
Unknown	10 (10)	1 (3)	6 (16)	3 (11)
N0	39 (39)	11 (31)	15 (41)	13 (48)	0.032
N1	20 (20)	5 (14)	11(30)	4 (15)
N2/3	18 (18)	12 (34)	3 (8)	3 (11)
Unknown	22 (22)	7 (20)	8 (22)	7 (26)
Stage I	9 (9)	2 (6)	6 (16)	1 (4)	0.236
Stage II	41 (41)	14 (40)	16 (43)	11 (41)
Stage III	39 (39)	18 (51)	9 (24)	12 (44)
Unknown	10 (10)	1 (3)	6 (16)	3 (11)
Stage IV	n/a	n/a	n/a	n/a

Table 3. Distribution of Grade, Molecular Subtype, Tumor Size, Nodal Status and Stage Across Age Groups in the KPH-R

Characteristics

Overall

Age < 50 years, N (%)

Age 50 - 59 years, N (%)

Age > 59 years, N (%)

P value (Chi-square)

KPH-R: Kingston Public Hospital Breast Cancer Registry.

Grade 1

8 (8)

0 (0)

4 (11)

4 (15)

0.119

Grade 2

44 (44)

18 (51)

13 (35)

13 (48)

Grade 3

39 (39)

15 (43)

16 (43)

8 (30)

Unknown

8 (8)

2 (6)

4 (11)

2 (7)

Total

99 (100)

35 (100)

37 (100)

27 (100)

Luminal A

48 (48)

14 (40)

19 (51)

15 (56)

0.777

Luminal B

10 (10)

3 (9)

5 (14)

2 (7)

HER2 enriched

7 (7)

4 (11)

1 (3)

2 (7)

Triple negative

21 (21)

7 (20)

9 (24)

5 (19)

Unknown

13 (13)

7 (20)

3 (8)

3 (11)

10 (10)

2 (6)

7 (19)

1 (4)

0.157

36 (36)

13 (37)

13 (35)

10 (37)

22 (22)

9 (26)

8 (22)

5 (19)

21 (21)

10 (29)

3 (8)

8 (30)

Unknown

10 (10)

1 (3)

6 (16)

3 (11)

39 (39)

11 (31)

15 (41)

13 (48)

0.032

20 (20)

5 (14)

11(30)

4 (15)

N2/3

18 (18)

12 (34)

3 (8)

3 (11)

Unknown

22 (22)

7 (20)

8 (22)

7 (26)

Stage I

9 (9)

2 (6)

6 (16)

1 (4)

0.236

Stage II

41 (41)

14 (40)

16 (43)

11 (41)

Stage III

39 (39)

18 (51)

9 (24)

12 (44)

Unknown

10 (10)

1 (3)

6 (16)

3 (11)

Stage IV

n/a