World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://www.wjon.org

Original Article

Volume 12, Number 6, December 2021, pages 232-239

Early mRNA Expression of Neuroendocrine Differentiation Signals Predicts Recurrence After Radical Prostatectomy: A Transcriptomic Analysis

Figures

Figure 1.
Figure 1. Oncoplot of mRNA expression (high, low, no alterations) among endothelin axis and NF-κB subunit genes.
Figure 2.
Figure 2. Bar graphs of the distribution between altered and unaltered groups of patients within different Gleason scores.
Figure 3.
Figure 3. Scatter plots depicting the correlation of mRNA expression between: (a) NFKB1 and RELA, (b) NFKB1 and EDNRA, (c) NFKB1 and EDNRB, (d) EDNRA and EDNRB genes.
Figure 4.
Figure 4. Kaplan Meier curve of BCR-free (disease-free) survival according to presence or absence of mRNA expression alterations in endothelin axis and NF-κB subunit genes. BCR: biochemical recurrence.
Figure 5.
Figure 5. Copy number loss in tumor suppressor genes between endothelin axis/NF-κB altered and unaltered groups.
Figure 6.
Figure 6. Gene expression of neuroendocrine differentiation signals between endothelin axis and NF-κB altered and unaltered groups.

Tables

Table 1. Clinical Characteristics of the Study Cohort (N = 122)
 
N (%)
Gleason score
  627 (22.1)
  764 (52.4)
  810 (8.2)
  910 (8.2)
T stage
  T163 (51.6)
  T247 (38.5)
  T36 (4.9)
  T41 (0.8)

 

Table 2. Copy Number Loss in Tumor Suppressor Genes Between Endothelin Axis and NF-κB Altered and Unaltered Groups
 
Genes and groupN (%)P valueq value
PTEN
  Altered10/69 (14.49)0.1480.598
  Unaltered4/57 (7.02)
RB1
  Altered5/69 (7.25)0.1540.598
  Unaltered1/57 (1.75)
TP53
  Altered2/69 (2.90)0.5720.600
  Unaltered1/57 (1.75)