World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website https://www.wjon.org

Original Article

Volume 13, Number 6, December 2022, pages 343-349

The Association Between Aspirin and Basal Cell Carcinoma: A Clinical and Financial Analysis

Figure 1. Diagram depicting the grouping of patients based on various criteria. BCC: basal cell carcinoma.

Figure 2. Percentage of patients with BCC compared by aspirin use and nonuse (P < 2.2 × 10^-16, OR = 0.54, 95% CI 0.47 - 0.61). BCC: basal cell carcinoma; OR: odds ratio; CI: confidence interval.

Figure 3. Average paid per patient for BCC treatment compared between aspirin use and nonuse (P = 0.0087). BCC: basal cell carcinoma.

**Table 1.** A Literature Review on Aspirin and Basal Cell Carcinoma Detailing the Inclusion of Various Criteria in Previous Studies
Study	Site	Region of residence known	Healthcare costs	Aspirin only	BCC only	> 1 US state	Self-reported
BCC: basal cell carcinoma.
Torti et al, 2011 [16]	Yes	Yes	No	No	No	No	Yes
Cahoon et al, 2012 [17]	Unclear	Yes	No	No	No	Yes	Yes
Clouser et al, 2009 [18]	No	Yes	No	No	No	No	Yes
Jeter et al, 2012 [10]	No	Yes	No	No	No	Yes	Yes
Johannesdottir et al, 2012 [19]	Yes	Yes	No	No	No	No	No
Ma et al, 2020 [20]	No	Yes	No	No	No	Yes	Partial
Muranushi et al, 2016 [21]	No	Partial	No	No	No	Yes	Partial
Passarelli et al, 2018 [22]	Yes	Yes	No	No	No	Yes	Yes
Reinau et al, 2015 [23]	No	Yes	No	No	No	No	No
Zhu et al, 2015 [24]	No	Yes	No	Yes	No	Yes	Partial
Frankel et al, 2022	Yes	Yes	Yes	Yes	Yes	Yes	No

Table 1. A Literature Review on Aspirin and Basal Cell Carcinoma Detailing the Inclusion of Various Criteria in Previous Studies

Study

Site

Region of residence known

Healthcare costs

Aspirin only

BCC only

> 1 US state

Self-reported

BCC: basal cell carcinoma.

Torti et al, 2011 [16]

Yes

Cahoon et al, 2012 [17]

Unclear

Yes

Clouser et al, 2009 [18]

Yes

Jeter et al, 2012 [10]

Yes

Johannesdottir et al, 2012 [19]

Yes

Ma et al, 2020 [20]

Yes

Partial

Muranushi et al, 2016 [21]

Partial

Yes

Partial

Passarelli et al, 2018 [22]

Yes

Reinau et al, 2015 [23]

Yes

Zhu et al, 2015 [24]

Yes

Partial

Frankel et al, 2022

Yes

**Table 2.** Descriptions of Financial Terms as Provided by PearlDiver National Database User Manual
Term	Description
Total paid	The sum of all reimbursements for claims captured by query represented in total, and for each set of criteria including: code, age, region, state, service location, year, and quarter.
Average paid/claim	The total reimbursement divided by the number of non-zero records represented in total, and for each set of criteria, including: code, age, region, state, service location, year, and quarter.
Average paid/event	The total reimbursement divided by the number of non-zero records represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.
Average paid/patient	The total reimbursement divided by the number patients represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.
Average length of stay	The average complete number of days reported per inpatient visit represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.

Table 2. Descriptions of Financial Terms as Provided by PearlDiver National Database User Manual

Term

Description

Total paid

The sum of all reimbursements for claims captured by query represented in total, and for each set of criteria including: code, age, region, state, service location, year, and quarter.

Average paid/claim

The total reimbursement divided by the number of non-zero records represented in total, and for each set of criteria, including: code, age, region, state, service location, year, and quarter.

Average paid/event

The total reimbursement divided by the number of non-zero records represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.

Average paid/patient

The total reimbursement divided by the number patients represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.

Average length of stay

The average complete number of days reported per inpatient visit represented in total and for each set of criteria including: code, age, region, state, service location, year, and quarter.