World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website https://www.wjon.org

Original Article

Volume 15, Number 1, February 2024, pages 126-135

Treatment Patterns and Survival Outcomes in Patients With Stage T1-2N0M0 Small Cell Lung Cancer Undergoing Surgery: A Retrospective Cohort Study

Figure 1. Flowchart illustrating the patient selection process. CRT: chemoradiotherapy; CT: chemotherapy; RT: radiotherapy; SCLC: small cell lung cancer.

**Table 1.** Patient Characteristics
	Surgery alone (n = 65)	Surgery + CT (n = 70)	Surgery + CRT (n = 52)	P
CRT: chemoradiotherapy; CT: chemotherapy.
Age				0.532
< 67	36 (55.4%)	32 (45.7%)	26 (50.0%)
≥ 67	29 (44.6%)	38 (54.3%)	26 (50.0%)
Sex				0.673
Female	41 (63.1%)	39 (55.7%)	30 (57.7%)
Male	24 (36.9%)	31 (44.3%)	22 (42.3%)
Race				0.423
White	61 (93.8%)	68 (97.1%)	49 (94.2%)
Black	3 (4.7%)	0 (0.0%)	2 (3.9%)
Others	1 (1.5%)	2 (2.9%)	1 (1.9%)
Site				0.575
Upper lobe	45 (69.2%)	44 (62.9%)	28 (53.8%)
Middle lobe	4 (6.2%)	5 (7.1%)	3 (5.8%)
Lower lobe	15 (23.1%)	20 (28.6%)	18 (34.6%)
Others	1 (1.5%)	1 (1.4%)	3 (5.8%)
Laterality				0.516
Left	30 (46.2%)	29 (41.4%)	27 (51.9%)
Right	35 (53.8%)	41 (58.6%)	25 (48.1%)
Grade				0.124
III/IV	45 (69.2%)	37 (52.9%)	34 (65.4%)
I/II/unknown	20 (30.8%)	33 (47.1%)	18 (34.6%)
T stage				0.363
T1N0M0	38 (58.5%)	48 (68.6%)	36 (69.2%)
T2N0M0	27 (41.5%)	22 (31.4%)	16 (30.8%)

Table 1. Patient Characteristics

Surgery alone (n = 65)

Surgery + CT (n = 70)

Surgery + CRT (n = 52)

CRT: chemoradiotherapy; CT: chemotherapy.

Age

0.532

< 67

36 (55.4%)

32 (45.7%)

26 (50.0%)

≥ 67

29 (44.6%)

38 (54.3%)

26 (50.0%)

Sex

0.673

Female

41 (63.1%)

39 (55.7%)

30 (57.7%)

Male

24 (36.9%)

31 (44.3%)

22 (42.3%)

Race

0.423

White

61 (93.8%)

68 (97.1%)

49 (94.2%)

Black

3 (4.7%)

0 (0.0%)

2 (3.9%)

Others

1 (1.5%)

2 (2.9%)

1 (1.9%)

Site

0.575

Upper lobe

45 (69.2%)

44 (62.9%)

28 (53.8%)

Middle lobe

4 (6.2%)

5 (7.1%)

3 (5.8%)

Lower lobe

15 (23.1%)

20 (28.6%)

18 (34.6%)

Others

1 (1.5%)

1 (1.4%)

3 (5.8%)

Laterality

0.516

Left

30 (46.2%)

29 (41.4%)

27 (51.9%)

Right

35 (53.8%)

41 (58.6%)

25 (48.1%)

Grade

0.124

III/IV

45 (69.2%)

37 (52.9%)

34 (65.4%)

I/II/unknown

20 (30.8%)

33 (47.1%)

18 (34.6%)

T stage

0.363

T1N0M0

38 (58.5%)

48 (68.6%)

36 (69.2%)

T2N0M0

27 (41.5%)

22 (31.4%)

16 (30.8%)

**Table 2.** Univariable Proportional Hazards Regressions
	Cancer-specific survival	Overall survival
CI: confidence interval; CRT: chemoradiotherapy; CT: chemotherapy; HR: hazard ratio.
Age
< 67	Reference			Reference
≥ 67	1.82	1.13 - 2.93	0.014	1.74	1.19 - 2.55	0.004
Sex
Female	Reference			Reference
Male	1.13	0.71 - 1.82	0.600	1.15	0.79 - 1.69	0.455
Race
White	Reference			Reference
Black	2.41	0.76 - 7.69	0.137	1.48	0.47 - 4.67	0.506
Others	1.52	0.37 - 6.22	0.559	1.55	0.49 - 4.89	0.458
Site
Upper lobe	Reference			Reference
Middle lobe	0.78	0.31 - 1.98	0.604	0.45	0.18 - 1.12	0.085
Lower lobe	0.80	0.47 - 1.38	0.427	0.69	0.45 - 1.07	0.100
Others	1.56	0.48 - 5.01	0.459	0.91	0.29 - 2.88	0.870
Laterality
Left	Reference			Reference
Right	0.67	0.42 - 1.07	0.093	0.68	0.47 - 0.99	0.047
Grade
III/IV	Reference			Reference
I/II/unknown	0.91	0.56 - 1.47	0.698	0.85	0.58 - 1.25	0.413
T stage
T1N0M0	Reference			Reference
T2N0M0	1.20	0.74 - 1.94	0.450	1.10	0.74 - 1.62	0.641
Treatment
Surgery alone	Reference			Reference
Surgery + CT	0.87	0.50 - 1.51	0.612	0.62	0.40 - 0.97	0.036
Surgery + CRT	0.94	0.52 - 1.70	0.839	0.76	0.48 - 1.21	0.253

Table 2. Univariable Proportional Hazards Regressions

Cancer-specific survival

Overall survival

95% CI

CI: confidence interval; CRT: chemoradiotherapy; CT: chemotherapy; HR: hazard ratio.

Age

< 67

Reference

≥ 67

1.82

1.13 - 2.93

0.014

1.74

1.19 - 2.55

0.004

Sex

Female

Reference

Male

1.13

0.71 - 1.82

0.600

1.15

0.79 - 1.69

0.455

Race

White

Reference

Black

2.41

0.76 - 7.69

0.137

1.48

0.47 - 4.67

0.506

Others

1.52

0.37 - 6.22

0.559

1.55

0.49 - 4.89

0.458

Site

Upper lobe

Reference

Middle lobe

0.78

0.31 - 1.98

0.604

0.45

0.18 - 1.12

0.085

Lower lobe

0.80

0.47 - 1.38

0.427

0.69

0.45 - 1.07

0.100

Others

1.56

0.48 - 5.01

0.459

0.91

0.29 - 2.88

0.870

Laterality

Left

Reference

Right

0.67

0.42 - 1.07

0.093

0.68

0.47 - 0.99

0.047

Grade

III/IV

Reference

I/II/unknown

0.91

0.56 - 1.47

0.698

0.85

0.58 - 1.25

0.413

T stage

T1N0M0

Reference

T2N0M0

1.20

0.74 - 1.94

0.450

1.10

0.74 - 1.62

0.641

Treatment

Surgery alone

Reference

Surgery + CT

0.87

0.50 - 1.51

0.612

0.62

0.40 - 0.97

0.036

Surgery + CRT

0.94

0.52 - 1.70

0.839

0.76

0.48 - 1.21

0.253