World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 2, Number 5, October 2011, pages 225-231

Comorbid Conditions in Patients With Metastatic Colorectal Cancer

**Table 1.** Characteristics of Study Population
Variable	n	Mean or percentage
SD: standard deviation; HMO: Health Maintenance Organization; PPO: Preferred Provider Organization; POS: Point of Service plan.
Age, mean ± SD, year	12 648	66.3 ± 13.1
18 ≤ Age < 40	240	1.9%
40 ≤ Age < 50	1012	8.0%
50 ≤ Age < 65	4819	38.1%
Age ≥ 65	6577	52.0%
Gender: male (versus female)	6855	54.2%
Geographic region
Northeast	1189	9.4%
North Central	4364	34.5%
South	4490	35.5%
West	2568	20.3%
Unknown	38	0.3%
Urban versus rural residence
Urban	10 245	81.0%
Rural	2353	18.6%
Missing	51	0.4%
Insurance plan type
Comprehensive	4174	33.0%
HMO	2125	16.8%
PPO	5059	40.0%
POS-non-capitated	734	5.8%
Other/unknown	557	4.4%
Cancer type: colon (versus rectum)	8866	70.1%
Location of metastasis
Liver	5084	40.2%
Lung	1796	14.2%
Bone	696	5.5%
Brain	379	3.0%
Others	4693	37.1%

Table 1. Characteristics of Study Population

Variable

Mean or percentage

SD: standard deviation; HMO: Health Maintenance Organization; PPO: Preferred Provider Organization; POS: Point of Service plan.

Age, mean ± SD, year

12 648

66.3 ± 13.1

18 ≤ Age < 40

240

1.9%

40 ≤ Age < 50

1012

8.0%

50 ≤ Age < 65

4819

38.1%

Age ≥ 65

6577

52.0%

Gender: male (versus female)

6855

54.2%

Geographic region

Northeast

1189

9.4%

North Central

4364

34.5%

South

4490

35.5%

West

2568

20.3%

Unknown

0.3%

Urban versus rural residence

Urban

10 245

81.0%

Rural

2353

18.6%

Missing

0.4%

Insurance plan type

Comprehensive

4174

33.0%

HMO

2125

16.8%

PPO

5059

40.0%

POS-non-capitated

734

5.8%

Other/unknown

557

4.4%

Cancer type: colon (versus rectum)

8866

70.1%

Location of metastasis

Liver

5084

40.2%

Lung

1796

14.2%

Bone

696

5.5%

Brain

379

3.0%

Others

4693

37.1%

**Table 2.** Comorbid conditions: numbers and percentages (N = 12 648)
Comorbidities*	Total population (n = 12 648)	Age < 65 (n = 6070)	Age ≥ 65 (n = 6578)	p-value (between < 65 and ≥ 65)
*Some patients had more than one type of comorbidity and are tabulated under each condition; VTE: venous thromboembolism; ATE: arterial thromboembolism.
Cardiovascular disease	7047	55.7	2581	42.5	4466	67.9	< 0.0001
Hypertension	5166	40.8	1990	32.8	3176	48.3	< 0.0001
Heart disease	3544	28.0	945	15.6	2599	39.5	< 0.0001
Coronary artery disease	1711	13.5	404	6.7	1307	19.9	< 0.0001
Acute myocarditis	1	0.0	0	0.0	1	0.0
Cardiomyopathy	234	1.9	69	1.1	165	2.5	< 0.0001
Cardiac dysrhythmia	1792	14.2	426	7.0	1366	20.8	< 0.0001
Congestive heart failure	905	7.2	174	2.9	731	11.1	< 0.0001
Acute myocardial infarction	215	1.7	58	1.0	157	2.4	< 0.0001
Other ischemic heart disease	785	6.2	232	3.8	553	8.4	< 0.0001
Stroke	497	3.9	108	1.8	389	5.9	< 0.0001
VTE	576	4.6	257	4.2	319	4.8	0.10
ATE	784	6.2	205	3.4	579	8.8	< 0.0001
Diabetes mellitus	2418	19.1	999	16.5	1419	21.6	< 0.0001
Existing wound	2006	15.9	962	15.8	1044	15.9	0.97
Digestive system	3668	29.0	1692	27.9	1976	30.0	0.007
Diseases of blood and blood forming organs	340	2.7	175	2.9	165	2.5	0.19
Diseases of skin and subcutaneous tissue	592	4.7	204	3.4	388	5.9	< 0.0001
Renal failure and insufficiency	989	7.8	348	5.7	641	9.7	< 0.0001
History of bleeding	3574	28.3	1825	30.1	1749	26.6	< 0.0001
Diseases of respiratory system	1974	15.6	629	10.4	1345	20.4	< 0.0001
Smoking history	49	0.4	28	0.5	21	0.3	0.20
Obesity	161	1.3	129	2.1	32	0.5	< 0.0001

Table 2. Comorbid conditions: numbers and percentages (N = 12 648)

Comorbidities*

Total population (n = 12 648)

Age < 65 (n = 6070)

Age ≥ 65 (n = 6578)

p-value (between < 65 and ≥ 65)

*Some patients had more than one type of comorbidity and are tabulated under each condition; VTE: venous thromboembolism; ATE: arterial thromboembolism.

Cardiovascular disease

7047

55.7

2581

42.5

4466

67.9

< 0.0001

Hypertension

5166

40.8

1990

32.8

3176

48.3

< 0.0001

Heart disease

3544

28.0

945

15.6

2599

39.5

< 0.0001

Coronary artery disease

1711

13.5

404

6.7

1307

19.9

< 0.0001

Acute myocarditis

0.0

Cardiomyopathy

234

1.9

1.1

165

2.5

< 0.0001

Cardiac dysrhythmia

1792

14.2

426

7.0

1366

20.8

< 0.0001

Congestive heart failure

905

7.2

174

2.9

731

11.1

< 0.0001

Acute myocardial infarction

215

1.7

1.0

157

2.4

< 0.0001

Other ischemic heart disease

785

6.2

232

3.8

553

8.4

< 0.0001

Stroke

497

3.9

108

1.8

389

5.9

< 0.0001

VTE

576

4.6

257

4.2

319

4.8

0.10

ATE

784

6.2

205

3.4

579

8.8

< 0.0001

Diabetes mellitus

2418

19.1

999

16.5

1419

21.6

< 0.0001

Existing wound

2006

15.9

962

15.8

1044

15.9

0.97

Digestive system

3668

29.0

1692

27.9

1976

30.0

0.007

Diseases of blood and blood forming organs

340

2.7

175

2.9

165

2.5

0.19

Diseases of skin and subcutaneous tissue

592

4.7

204

3.4

388

5.9

< 0.0001

Renal failure and insufficiency

989

7.8

348

5.7

641

9.7

< 0.0001

History of bleeding

3574

28.3

1825

30.1

1749

26.6

< 0.0001

Diseases of respiratory system

1974

15.6

629

10.4

1345

20.4

< 0.0001

Smoking history

0.4

0.5

0.3

0.20

Obesity

161

1.3

129

2.1

0.5

< 0.0001

**Table 3.** Medications Received Prior to Diagnosis of mCRC (N = 12 648)
Variable	Number	Percentage (%)
NSAIDs: non-steroidal anti-inflammatory drugs.
Cardiac drugs
Antihypertensives	6286	49.7
Other cardiac drugs	4123	32.6
Anticoagulant	1492	11.8
Antiplatelet drugs	734	5.8
Vasodilating drugs	734	5.8
Antibiotics	7804	61.7
Antihyperlipidemics	3719	29.4
Diuretics	3036	24.0
NSAIDs	2188	17.3
Antiallergic drugs	1986	15.7
Antidiabetic drugs	1935	15.3
Antidiarrhoea drugs	1075	8.5
Anticonvulsants	974	7.7
H2 antagonists	696	5.5
Antiulcer	696	5.5

Table 3. Medications Received Prior to Diagnosis of mCRC (N = 12 648)

Variable

Number

Percentage (%)

NSAIDs: non-steroidal anti-inflammatory drugs.

Cardiac drugs

Antihypertensives

6286

49.7

Other cardiac drugs

4123

32.6

Anticoagulant

1492

11.8

Antiplatelet drugs

734

5.8

Vasodilating drugs

734

5.8

Antibiotics

7804

61.7

Antihyperlipidemics

3719

29.4

Diuretics

3036

24.0

NSAIDs

2188

17.3

Antiallergic drugs

1986

15.7

Antidiabetic drugs

1935

15.3

Antidiarrhoea drugs

1075

8.5

Anticonvulsants

974

7.7

H2 antagonists

696

5.5

Antiulcer

696

5.5