| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Original Article
Volume 2, Number 5, October 2011, pages 245-251
“Short Course” of Nonpegylated Liposomal Doxorubicin Plus Paclitaxel and Trastuzumb as Primary Systemic Therapy for Operable and Locally-Advanced Breast Cancer: A Phase II Study (PacLiDox 07)
Tables
| Patients | Numbers/value of characteristics |
|---|---|
| *Fluorescence In-Situ Hybridation not amplified. | |
| Total | 30 |
| Age (median) | 58.5 (31-73) |
| Baseline stage | |
| IIA | 6 |
| IIB | 4 |
| IIIA | 11 |
| IIIB | 9 |
| Menopausal Status | |
| Post | 18 |
| Pre | 12 |
| Hormonal Receptor | |
| EgR positive | 25 |
| EgR negative | 5 |
| EgR/PgR negative | 4 |
| HER2-status | |
| 0 | 9 |
| 1 | 9 |
| 2 | 5* |
| 3 | 7 |
| Number of patients | Percentage (%) | |
|---|---|---|
| Complete response | 8 | 27 |
| Partial response | 10 | 33 |
| Minimal response | 4 | 13 |
| Stable disease | 7 | 24 |
| Progressive disease | 1 | 3 |
| pCR | 1 | 3 |
| No residual tumor on breast | 2 | 6 |
| Gr. 2 | Gr. 3 | Gr. 4 | |
|---|---|---|---|
| *1 febrile neutropenia. | |||
| Neutropenia | 5 | 10* | 3* |
| Anemia | 1 | 0 | 0 |
| Nausea | 8 | 0 | 0 |
| Vomiting | 0 | 1 | 0 |
| Joint symptoms | 3 | 1 | 0 |
| Asthenia | 0 | 1 | 0 |
| Diarrhoea | 1 | 0 | 0 |
| Neuropathy | 2 | 0 | 0 |
| Hepatotoxicity | 4 | 0 | 0 |