World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Original Article

Volume 3, Number 1, February 2012, pages 16-22


Early Experiences of Image Guided Prostate and Pelvic Nodal Irradiation With Intensity Modulated Radiation Treatment in Localized Prostate Cancer

Figure

Figure 1.
Figure 1. Axial View of Conformal IMRT Isodoses in Pelvis (a, b). Sagittal View of Conformal IMRT Isodoses in Pelvis (c)

Tables

Table 1. Characteristics of Study Patients
 
CharacteristicsValue
Number of patients12
Median age (years)64
Age range (years)50 - 74
Clinical stage
  T15
  T26
  T31
  T40
  Tx0
Gleason sum
  ≤ 60
  72
  85
  95
  100
PSA (ng/L)
  < 40
  4 - 103
  > 10, < 204
  > 205

 

Table 2. Toxicity Associated With Treatment
 
ToxicityNumber of patients
Acute GU Grade 1, 28/12
Acute GI Grade 1, 210/12
Late GU Grade 1, 26/12
Late GI Grade 1, 25/12

 

Table 3. Comparison of GU and GI Toxicities in Selected TArials
 
StudyRTOG 92-02EORTC 22863UK studyNorwegian studyNCI study
Acute GU G 1, 2529/758 (70%)71/79 (90%)36/43 (84%)8/12 (67%)
Acute GU G 3, 425/758 (3%)7%1/79 (1.3%)1/43 (2%)0%
Acute GI G 1, 2666/758 (88%)74/79 (94%)34/43 (79%)10/12 (83%)
Acute GI G 3, 411/201 (5.5%)5%1/79 (1.3%)0%0%
Late GU G 1, 212.5% (Gr 2 only)12.5% (Gr2 only)2.5% (Gr 2)20/43 (47%)6/12 (50%), 25% (Gr 2 only)
Late GU G 3, 43.4%3.4%2.5%1/43 (2%)0%
Late GI G 1, 29.5% (Gr 2 only)9.5% (Gr 2 only)25%22/43 (51%)5/12(42%), 8% (Gr 2 only)
Late GI G 3, 40.3%0.3%1.3%0%0%