World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 3, Number 3, June 2012, pages 113-118

The Role of Multi Detector Computed Tomographic Imaging Prior to Clinic Consultation in Patients Suspected to Have Lung Cancer

Tables

**Table 1.** Showing the Distribution of Patients Into Various Categories and the Respective Risk Scores
n = 124	Malignancy 53 (43%)		No Malignancy 71 (57%)
*unpaired t test, P = ns; ∧chi-square test, P < 0.0001.
Age (mean (SEM))*	69 (1.52)		67 (1.59)
Abnormality in %	Lung	89	None	21
	Metastasis	7	Insignificant	24
	Others	4	Significant	55
CXR score in %	0	0	0	21
	1	23	1	24
	2	77	2	55
Clinical risk score in %	0	2	0	31
	1	36	1	63
	2	62	2	6
MCRS∧ in %	0-2 (Low)	25	0-2 (Low)	85
	3 (Intermediate)	13	3 (Intermediate)	10
	4 (High)	62	4 (High)	6

**Table 2.** Logistic Regression Showing Significant Increase in Risk of Malignancy With Increasing MCRS and no Significant Influence of Age on Prediction of Malignancy
Logistic Regression Dichotomous dependent variable: Lung cancer
Predictor variables	B (SE)	Wald’s χ²	P	Odds Ratio (95% CI)
Goodness-of-fit test: Hosmer and Lemeshow; χ² = 11.576, P = 0.171; Nagelkerke R² = 0.499, c-statistic = 84.9%; Model accuracy in classification = 81.5%, Improvement in classification from baseline = 24.2%; Sensitivity = 69.81%, Specificity = 90.14%, PPV = 84.09%, NPV = 80%.
Age	0.023(0.020)	1.371	0.242	1.024 (0.984 - 1.065)
MCRS		36.270	< 0.0001
MCRS (1) (L with M)	-1.509 (0.621)	5.900	0.015	0.221 (0.065 - 0.747)
MCRS (2) (M with H)	-2.191 (0.764)	8.225	0.004	0.112 (0.025 - 0.500)

**Table 3.** Algorithm Incorporating MCRS and Age
Modified Combined risk score (MCRS)	Below 40 yrs	Above 40 yrs
High (4)	Staging CT	Staging CT
Intermediate (3)	Focused CT thorax	Staging CT
Low (0-2)	Review in clinic	Focused CT Thorax