World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 3, Number 6, December 2012, pages 280-285

Quality of Life in Patients With Primary and Metastatic Brain Tumors in the Literature as Assessed by the FACT-Br

**Table 1.** Included Studies
Author	Year	Type	No. of patients	In/Outpatient	PWB	SWB	EWB	FWB	Concerns	Overall	KPS MED
PWB: physical well-being; SWB: social well-being; EWB: emotional well-being; FWB: functional well-being; KPS: Karnofsky Performance Status; MED: median; n/a: not available.
Weitzner [20]	1995	PRIMARY	101	Outpatient	22.25	21.73	15.96	19.92	n/a	n/a	n/a
Sutton [17]	1999	PRIMARY	22	Inpatient	24	24	17	24	n/a	n/a	n/a
Huang [19]	2001	PRIMARY	10	Inpatient	n/a	n/a	n/a	n/a	n/a	103	n/a
Pelletier [2]	2002	PRIMARY	60	n/a	n/a	n/a	15.6	n/a	n/a	136.3	n/a
Roa (1st arm) [25]	2004	PRIMARY	47	n/a	n/a	n/a	n/a	n/a	n/a	75.1	70
Roa (2nd arm) [25]	2004	PRIMARY	48	n/a	n/a	n/a	n/a	n/a	n/a	77.7	70
Brown [22]	2006	PRIMARY	190	n/a	n/a	n/a	n/a	n/a	n/a	62	n/a
Shaw [9]	2006	PRIMARY	34	n/a	20.7	20.2	17.9	18	47.6	124.4	n/a
Locke [7]	2007	PRIMARY	205	n/a	81.3	n/a	72.4	n/a	69.2	72.8	n/a
Locke (1st arm) [8]	2008	PRIMARY	7	n/a	n/a	n/a	n/a	n/a	n/a	132	n/a
Locke (2nd arm) [8]	2008	PRIMARY	12	n/a	n/a	n/a	n/a	n/a	n/a	117	n/a
Jones [16]	2009	PRIMARY	171	n/a	22	23	19	19	50	133	90
Kvale [11]	2009	PRIMARY	50	Inpatient	21.2	23.3	19	15.1	48.8	127.33	n/a
Liu [23]	2009	PRIMARY	65	n/a	23	24.1	17.7	18.2	n/a	n/a	90
Mobed [15]	2009	PRIMARY	718	n/a	20.9	22.7	17.4	16.4	51.6	129	90
Lucchiari (1st arm) [5]	2010	PRIMARY	27	Inpatient	21.62	21.69	20.62	13.99	49.16	127.08	n/a
Lucchiari (2nd arm) [5]	2010	PRIMARY	29	Inpatient	20.73	17.69	17.69	14.13	47.48	117.72	n/a
Lucchiari (3rd arm) [5]	2010	PRIMARY	28	Inpatient	21.94	16.77	17.27	14.17	53	123.15	n/a
Lamperti [5]	2011	PRIMARY	81	n/a	22.92	18.54	17.86	14.15	n/a	n/a	n/a
Ruiz [14]	2011	PRIMARY	18	n/a	21	24.1	18.5	16.5	47.1	127.2	n/a
Terasaki [21]	2011	PRIMARY	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	60
Bezjak [4]	2002	METASTATIC	75	n/a	n/a	n/a	n/a	n/a	n/a	123.1	n/a
Rogers [18]	2006	METASTATIC	71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	90
Chang (1st Arm) [12]	2009	METASTATIC	30	n/a	n/a	n/a	n/a	n/a	n/a	64.6	70
Chang (2nd Arm) [12]	2009	METASTATIC	28	n/a	n/a	n/a	n/a	n/a	n/a	59.8	80
Ma [24]	2009	METASTATIC	21	n/a	13.8	10.7	12.1	6.2	26.6	69.1	n/a

Table 1. Included Studies

Author

Year

Type

No. of patients

In/Outpatient

PWB

SWB

EWB

FWB

Concerns

Overall

KPS MED

PWB: physical well-being; SWB: social well-being; EWB: emotional well-being; FWB: functional well-being; KPS: Karnofsky Performance Status; MED: median; n/a: not available.

Weitzner [20]

1995

PRIMARY

101

Outpatient

22.25

21.73

15.96

19.92

n/a

Sutton [17]

1999

PRIMARY

Inpatient

n/a

Huang [19]

2001

PRIMARY

Inpatient

n/a

103

n/a

Pelletier [2]

2002

PRIMARY

n/a

15.6

n/a

136.3

n/a

Roa (1st arm) [25]

2004

PRIMARY

n/a

75.1

Roa (2nd arm) [25]

2004

PRIMARY

n/a

77.7

Brown [22]

2006

PRIMARY

190

n/a

Shaw [9]

2006

PRIMARY

n/a

20.7

20.2

17.9

47.6

124.4

n/a

Locke [7]

2007

PRIMARY

205

n/a

81.3

n/a

72.4

n/a

69.2

72.8

n/a

Locke (1st arm) [8]

2008

PRIMARY

n/a

132

n/a

Locke (2nd arm) [8]

2008

PRIMARY

n/a

117

n/a

Jones [16]

2009

PRIMARY

171

n/a

133

Kvale [11]

2009

PRIMARY

Inpatient

21.2

23.3

15.1

48.8

127.33

n/a

Liu [23]

2009

PRIMARY

n/a

24.1

17.7

18.2

n/a

Mobed [15]

2009

PRIMARY

718

n/a

20.9

22.7

17.4

16.4

51.6

129

Lucchiari (1st arm) [5]

2010

PRIMARY

Inpatient

21.62

21.69

20.62

13.99

49.16

127.08

n/a

Lucchiari (2nd arm) [5]

2010

PRIMARY

Inpatient

20.73

17.69

14.13

47.48

117.72

n/a

Lucchiari (3rd arm) [5]

2010

PRIMARY

Inpatient

21.94

16.77

17.27

14.17

123.15

n/a

Lamperti [5]

2011

PRIMARY

n/a

22.92

18.54

17.86

14.15

n/a

Ruiz [14]

2011

PRIMARY

n/a

24.1

18.5

16.5

47.1

127.2

n/a

Terasaki [21]

2011

PRIMARY

n/a

Bezjak [4]

2002

METASTATIC

n/a

123.1

n/a

Rogers [18]

2006

METASTATIC

n/a

Chang (1st Arm) [12]

2009

METASTATIC

n/a

64.6

Chang (2nd Arm) [12]

2009

METASTATIC

n/a

59.8

Ma [24]

2009

METASTATIC

n/a

13.8

10.7

12.1

6.2

26.6

69.1

n/a

**Table 2.** Weighted Means of KPS and FACT-Br Subscale Scores
	Primary Brain Tumors	Metastatic Brain Tumor	P-value†
* NA: not available because there was only one study with available subscales; †: P-value was obtained by weighted analysis of variance; natural log-transformation was applied for KPS, FACT-Br subscales, and overall scale.
KPS	1,075	87.51 (104.61)	129	83.18 (66.32)	0.6631
Physical well-being	1,549	29.38 (230.56)	21	13.8 (NA*)	0.5952
Social well-being	1,344	22.23 (17.54)	21	10.7 (NA)	0.0026
Emotional well-being	1,609	24.58 (203.53)	21	12.10 (NA)	0.6412
Functional well-being	1,344	16.92 (20.34)	21	6.20 (NA)	0.0025
Brain subscale: Concerns related to Brain Metastasis	1,280	53.81 (86.37)	21	26.60 (NA)	0.0619
Overall Scale	1,654	111.27 (290.24)	154	92.83 (212.13)	0.4386

Table 2. Weighted Means of KPS and FACT-Br Subscale Scores

Primary Brain Tumors

Metastatic Brain Tumor

P-value†

Sum of Weight

Weighted Mean (SD)

Sum of Weight

Weighted Mean (SD)

* NA: not available because there was only one study with available subscales; †: P-value was obtained by weighted analysis of variance; natural log-transformation was applied for KPS, FACT-Br subscales, and overall scale.

KPS

1,075

87.51 (104.61)

129

83.18 (66.32)

0.6631

Physical well-being

1,549

29.38 (230.56)

13.8 (NA*)

0.5952

Social well-being

1,344

22.23 (17.54)

10.7 (NA)

0.0026

Emotional well-being

1,609

24.58 (203.53)

12.10 (NA)

0.6412

Functional well-being

1,344

16.92 (20.34)

6.20 (NA)

0.0025

Brain subscale: Concerns related to Brain Metastasis

1,280

53.81 (86.37)

26.60 (NA)

0.0619

Overall Scale

1,654

111.27 (290.24)

154

92.83 (212.13)

0.4386