World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Review

Volume 4, Number 2, April 2013, pages 67-73


An Update on the Quality of Life Measurements in Lung Cancer Patients Receiving Palliative Radiotherapy: A Literature Review

Tables

Table 1. Patients With Symptomatic Lung Cancer Treated With Endobronchial Brachytherapy (EBB) Compared to External Beam Radiotherapy With or Without EBB
 
*This study performed endobronchial brachytherapy on patients without non-small-cell lung cancer; ** This study uses both EBB as well as XRT. RCT: randomized controlled trial; TRT: thoracic radiotherapy; Gy: gray; fr: fractions; EORTC: European Organization for Research and Treatment of Cancer; NSCLC: non-small cell lung cancer; KPS: Karnofsky performance status; TOI: trial outcome index; MRC: Medical Research Council; FACT: Functional Assessment of Cancer Therapy; ECOG: Eastern Cooperative Oncology Group; RSCL: Rotterdam Symptom checklist; HDR: high dose rate.
*Stranzl et al, 2002 [9]ProspectiveEvaluate efficacy of Ir-192 HDR endobronchial brachytherapy for palliation of symptoms15-20Gy/3-4fr in 5-6Gy once a week11Not statedNoneNoneStudy Designed: Subjective assessment of symptoms
Mallick et al, 2007 [11]RCTTesting endobronchial brachytherapy to improve QOLA: 30Gy/10fr
B: 10Gy/fr
C: 15Gy/fr
114Not statedEORTC QLQ-C30 and QLQ-LC13 (2)KPSStudy designed: physician graded symptom improvements
**Stout et al, 2000 [19]RCTEvaluate QOL outcomes of patients receiving palliative treatmentA: 15Gy/fr
B: 30Gy/8fr
99287 days (A), 250 days (B)NoneWHORSCL, HADS
Skowronek et al, 2011 [23]ProspectiveDemonstrate use and impact of brachytherapyA: 22.5Gy/3fr
B: 10Gy/1fr
C: 7.5Gy/4fr
648Not statedNoneKPSNone

 

Table 2. Patients With Inoperable Lung Cancer (Other Than NSCLC) Treated With Palliative Radiotherapy
 
QOL: quality of life; KPS: Karnofsky performance status; fr: fractions; WHO: World Health Organization; EORTC: European Organization for Research and Treatment of Cancer; ECOG: Eastern Cooperative Oncology Group; HADS: Hospital Anxiety and Depression Scale; RSCL: Rotterdam symptom checklist; MRC: Medical Research Council; LCSS: Lung Cancer Symptom Scale; ESAS: Edmonton Symptom Assessment System; TOI: trial outcome index; FACT: Functional Assessment of Cancer Therapy; EBB: Endobronchial brachytherapy; XRT: external beam radiotherapy.
Caissie et al, 2011 [10]RetrospectiveAssess QOL with EORTC C-15 PAL in radiotherapy patientsNot stated29Not statedEORTC QLQ-C15-PAL (1)KPSNone
Zeng et al, 2011 [18]RCTReport impact of fatigue in cancer patientsNot stated500Not statedNoneKPSESAS, Study designed: 4 grade scale to rate fatigue
Janda et al, 2004 [14]RCTMeasuring QOL in radiotherapy patientsNot stated288Not statedEORTC QLQ-C30NoneNone

 

Table 3. Frequency of Instruments Used in Clinical Trials Measuring Quality of Life (QOL) in Patients With Locally Advanced Lung Cancer or Lung Metastases
 
InstrumentFrequency
European Organization for Research and Treatment of Cancer (EORTC)
  General cancer questionnaire (EORTC QLQ - C30)5
  Lung cancer questionnaire (EORTC QLQ - LC-13)4
  General cancer questionnaire (EORTC QLQ - C15 PAL)1
Functional Assessment of Cancer Therapy (FACT)
  Lung questionnaire (FACT - L)2
  Rotterdam Symptom Check-list4
  Hospital Anxiety and Depression Scale (HADS)3
  Trial Outcome Index (TOI)2
  Lung Cancer Symptom Scale (LCSS)1
  Edmonton Symptom Assessment System (ESAS)1