World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Case Report

Volume 4, Number 2, April 2013, pages 122-125


Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy

Figure

Figure 1.
Figure 1. MRI appearances of brain metastases before (pre-TCH, above) and after drug treatment (post-TCH, below). Fluid attenuated inversion recovery (FLAIR) images are shown at left, and T1-weighted images at right.

Table

Table 1. Molecular Weights of Relevant Oncology Drugs
 
DrugReported efficacy in solid tumour cerebral metastasesMWt (Da)
The putative blood-brain barrier cut-off is 400 Da. MWt: molecular weight; Da: daltons.
Capecitabine+360
Carboplatin+371
Tamoxifen+372
Megestrol acetate+384
Gefitinib+447
Doxorubicin-580
Etoposide+587
Docetaxel-808
Lapatinib+944
Trastuzumab+148,000