World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 5, Number 5-6, December 2014, pages 196-203

Bacterial Spectrum, Isolation Sites and Susceptibility Patterns of Pathogens in Adult Febrile Neutropenic Cancer Patients at a Specialist Hospital in Saudi Arabia

**Table 1.** Frequency of Malignancy Type
Malignancy type	Number	Frequency (%)
Solid tumors
Colorectal	14	13.21
Breast	13	12.26
Pancreatic	6	5.66
Gall bladder	4	3.77
Lung	4	3.77
Sarcoma	3	2.83
Prostate	2	1.88
Uterus	2	1.88
Others	9	8.49
Total frequency of solid tumors	57	53.77
Hematology
Leukemia
Acute myeloid leukemia	16	15.09
Acute lymphoblastic leukemia	6	5.66
Lyphoma
Non-Hodgkin’s lymphoma	21	19.81
Hodgkin’s lymphoma	1	0.94
Myeloma
Multiple myeloma	5	4.72
Total frequency of hematology	49	46.23

Table 1. Frequency of Malignancy Type

Malignancy type

Number

Frequency (%)

Solid tumors

Colorectal

13.21

Breast

12.26

Pancreatic

5.66

Gall bladder

3.77

Lung

3.77

Sarcoma

2.83

Prostate

1.88

Uterus

1.88

Others

8.49

Total frequency of solid tumors

53.77

Hematology

Leukemia

Acute myeloid leukemia

15.09

Acute lymphoblastic leukemia

5.66

Lyphoma

Non-Hodgkin’s lymphoma

19.81

Hodgkin’s lymphoma

0.94

Myeloma

Multiple myeloma

4.72

Total frequency of hematology

46.23

**Table 2.** Frequency of Gram-Positive and Gram-Negative Pathogens
Malignancy type	Gram-positive	Frequency (%)	Gram-negative	Frequency (%)
Solid tumors	22	28.95	54	71.05
Hematology	25	40.32	37	59.68

Table 2. Frequency of Gram-Positive and Gram-Negative Pathogens

Malignancy type

Gram-positive

Frequency (%)

Gram-negative

Frequency (%)

Solid tumors

28.95

71.05

Hematology

40.32

59.68

**Table 3.** Frequency of Pathogens at Isolated Sites
Isolation sites	Gram-positive	%	Gram-negative	%
Blood	23	16.7	23	16.7
Urine	6	4.35	35	25.36
Wound	15	10.86	12	8.69
Body fluids	1	0.72	12	8.69
Sputum	2	1.44	9	6.52

Table 3. Frequency of Pathogens at Isolated Sites

Isolation sites

Gram-positive

Gram-negative

Blood

16.7

Urine

4.35

25.36

Wound

10.86

8.69

Body fluids

0.72

8.69

Sputum

1.44

6.52

**Table 4.** Frequency of Gram-Positive Bacterial Isolates in Febrile Neutropenia
Gram-positive bacteria	Blood culture	Urine culture	Sputum culture	Wound culture	Body fluids culture	Total (%)
Staphylococcus aureus	5	-	1	11	1	18 (13.04%)
Staphylococcus spp. (CoNS)	4	1	-	1	-	6 (4.35%)
Streptococcus spp.	6	2	1	1	-	10 (7.25%)
Enterococcus spp.	4	3	-	1	-	8 (5.80%)
Corynebacterium spp.	4	-	-	1	-	5 (3.62%)
Overall frequency	47 (34.06%)

Table 4. Frequency of Gram-Positive Bacterial Isolates in Febrile Neutropenia

Gram-positive bacteria

Blood culture

Urine culture

Sputum culture

Wound culture

Body fluids culture

Total (%)

Staphylococcus aureus

18 (13.04%)

Staphylococcus spp. (CoNS)

6 (4.35%)

Streptococcus spp.

10 (7.25%)

Enterococcus spp.

8 (5.80%)

Corynebacterium spp.

5 (3.62%)

Overall frequency

47 (34.06%)

**Table 5.** Frequency of Gram-Negative Isolates in Febrile Neutropenia
Gram-negative bacteria	Blood culture	Urine culture	Sputum culture	Wound culture	Body fluids culture	Total (%)
Escherichia coli	9	20	1	5	7	42 (30.43%)
Klebsiella pneumoniae	7	6	3	2	2	20 (14.49%)
Pseudomonas spp.	1	2	4	3	-	10 (7.25%)
Enterobacter spp.	2	2	-	-	1	5 (3.62%)
Acinobacter spp.	2	2	-	-	-	4 (2.90%)
Serratia marcescens	-	2	-	-	1	3 (2.17%)
Proteus mirabilis	-	-	-	2	-	2 (1.45%)
Aeromonas hydrophylia	1	-	-	-	-	1 (00.72%)
Citrobacter freundii	-	1	-	-	-	1 (0.72%)
Providencia stuartii	1	-	-	-	-	1 (0.72%)
Sphingomonas paucimobilis	-	-	-	-	1	1 (0.72%)
Stenotropomonas multipholia	-	-	1	-	-	1 (0.72%)
Overall frequency	91 (65.94%)

Table 5. Frequency of Gram-Negative Isolates in Febrile Neutropenia

Gram-negative bacteria

Blood culture

Urine culture

Sputum culture

Wound culture

Body fluids culture

Total (%)

Escherichia coli

42 (30.43%)

Klebsiella pneumoniae

20 (14.49%)

Pseudomonas spp.

10 (7.25%)

Enterobacter spp.

5 (3.62%)

Acinobacter spp.

4 (2.90%)

Serratia marcescens

3 (2.17%)

Proteus mirabilis

2 (1.45%)

Aeromonas hydrophylia

1 (00.72%)

Citrobacter freundii

1 (0.72%)

Providencia stuartii

1 (0.72%)

Sphingomonas paucimobilis

1 (0.72%)

Stenotropomonas multipholia

1 (0.72%)

Overall frequency

91 (65.94%)

**Table 6.** Susceptibility of Gram-Negative and Gram-Positive Isolates
AM: amikacin; CF: ciprofloxacin; GM: gentamycin; IC: imipenem-cilastatin; PT: piperacillin-tazobactam; CT: ceftriaxone; VM: vancomycin; LF: levofloxacin; LZ: linezolid; OC: oxacillin.
Gram-negative isolates	Isolates	AM	CF	GM	IC	PT	CT
Escherichia coli	42	91.6	47.1	67.36	99.86	83.15	62.06
Klebsiella pneumonae	20	95.24	75.42	82.12	98.96	69.48	77.78
Pseudomonas aeugenosa	10	88.92	82.62	88.52	81.16	82.28	0
Enterbacter cloacae	5	93.52	82.36	86.92	100	66.9	60.76
Acinobacter baumanii	4	67.32	34.5	52.86	43.74	28.14	2.45
Serratia marscences	3	100	95	97.34	100	93.2	88.6
Proteus mirabilis	2	95.98	68.36	77.34	94.38	93.52	85.5
Gram-positive isolates	Isolates	CF	GM	VM	LF	LZ	CT	OC
Staphylococcus aureus	18	72.05	89.38	100	74.36	100	0	71.38
Streptococcus pneumoniae	10	100	100	100	100	100	96.9	69.1
Enterococcus spp.	8	51.45	35.65	98.82	63.04	96.58	0	0
Coagulase-negative Staphylococcus	6	38.7	53.1	99.76	38.5	99.22	0	12.88

Table 6. Susceptibility of Gram-Negative and Gram-Positive Isolates

AM: amikacin; CF: ciprofloxacin; GM: gentamycin; IC: imipenem-cilastatin; PT: piperacillin-tazobactam; CT: ceftriaxone; VM: vancomycin; LF: levofloxacin; LZ: linezolid; OC: oxacillin.

Gram-negative isolates

Isolates

Escherichia coli

91.6

47.1

67.36

99.86

83.15

62.06

Klebsiella pneumonae

95.24

75.42

82.12

98.96

69.48

77.78

Pseudomonas aeugenosa

88.92

82.62

88.52

81.16

82.28

Enterbacter cloacae

93.52

82.36

86.92

100

66.9

60.76

Acinobacter baumanii

67.32

34.5

52.86

43.74

28.14

2.45

Serratia marscences

100

97.34

100

93.2

88.6

Proteus mirabilis

95.98

68.36

77.34

94.38

93.52

85.5

Gram-positive isolates

Isolates

Staphylococcus aureus

72.05

89.38

100

74.36

100

71.38

Streptococcus pneumoniae

100

96.9

69.1

Enterococcus spp.

51.45

35.65

98.82

63.04

96.58

Coagulase-negative Staphylococcus

38.7

53.1

99.76

38.5

99.22

12.88