| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Original Article
Volume 7, Number 5-6, December 2016, pages 98-103
Rectal Toxicity After Extremely Hypofractionated Radiotherapy Using a Non-Isocentric Robotic Radiosurgery System for Early Stage Prostate Cancer
Tables
| PTV: planning target volume; D (x mL): radiation dose covered irradiated volume (x mL); D (x %): irradiated volume (x % of the risk organ or target volume) covered by high radiation dose; Dmax: maximum point-dose which is allowed. | |
| PTV | D (1 mL) < 42 Gy |
| D (95%) ≥ 35 Gy | |
| D (98%) ≥ 33.25 Gy | |
| Rectum | D (1 mL) ≤ 36.75 Gy |
| D (3 mL) ≤ 33.25 Gy | |
| D (10%) ≤ 31.5 Gy | |
| D (20%) ≤ 28 Gy | |
| D (50%) ≤ 17.5 Gy | |
| Colon | Dmax ≤ 38 Gy |
| D (20 mL) < 25 Gy | |
| Bladder | D (1 mL) < 38 Gy |
| D (10%) ≤ 31.5 Gy | |
| D (50%) ≤ 17.5 Gy | |
| Urethra | D (1 mL) < 37.45 Gy |
| Penile bulb | Dmax ≤ 35 Gy |
| D (3 mL) < 20 Gy | |
| Femoral head | Dmax ≤ 30 Gy |
| D (10 mL) < 20 Gy | |
| Number of patients (%) | ||
|---|---|---|
| IPSS: international prostate symptom score; PSA: prostate specific antigen; CTV: clinical target volume; PTV: planning target volume. | ||
| Median age (range) | 70 years (57 - 78) | |
| Initial IPSS | ||
| 0 - 5 | 12 (60) | |
| 6 - 10 | 4 (20) | |
| 11 - 16 | 4 (20) | |
| Initial PSA (range) | 6.92 ng/mL (3.3 - 14.32) | |
| < 10 ng/mL | 18 (90) | |
| > 10 ng/mL | 2 (10) | |
| Gleason score | ||
| 3+3 | 14 (70) | |
| 3+4 | 3 (15) | |
| 4+3 | 3 (15) | |
| Clinical T stage | ||
| T1c | 16 (80) | |
| T2a | 2 (10) | |
| T2b | 1 (5) | |
| T2c | 1 (5) | |
| Risk group | ||
| Low-risk | 12 (60) | |
| Intermediate-risk | 8 (40) | |
| Hormonal therapy | ||
| Yes | 2 (10) | |
| No | 18 (90) | |
| Median CTV volume (range) | 23.75 mL (11.1 - 99.0) | |
| Median PTV volume (range) | 50.3 mL (27.6 - 155.7) | |
| Dosimetric parameters | Number of patients | ≥ grade 2 rectal toxicity (%) | P value |
|---|---|---|---|
| Rectum-Vx Gy: % rectal volume receiving > x Gy. | |||
| Maximum dose | |||
| < 38 Gy | 11 | 27.2 | 0.752 |
| ≥ 38 Gy | 5 | 20.0 | |
| Rectum-V31.5 Gy | |||
| < 2 mL | 6 | 16.6 | 0.542 |
| ≥ 2 mL | 10 | 30.0 | |
| Rectum-V28 Gy | |||
| < 3.8 mL | 5 | 0 | 0.058 |
| ≥ 3.8 mL | 11 | 36.3 | |
| Rectum-V24 Gy | |||
| < 7 mL | 8 | 12.5 | 0.239 |
| ≥ 7 mL | 8 | 37.5 | |
| Rectum-V17.5 Gy | |||
| < 12 mL | 7 | 14.2 | 0.372 |
| ≥ 12 mL | 9 | 25.0 | |