World Journal of Oncology


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Frequency: Bimonthly
Journal Access: Open Access

ISSN-print: 1920-4531

ISSN-online: 1920-454X
Journal scope: World Journal of Oncology is an open access, peer-reviewed, international journal, publishes original contributions describing basic research and clinical investigation of cancer, on the cellular, molecular, prevention, diagnosis, therapy and prognosis aspects. The submissions can be basic research or clinical investigation oriented.
Indexed and covered: Chemical Abstracts (CA); Directory of Open Access Journals (DOAJ); JournalTOCs; Google Scholar; PubMed and PubMed Central: selected citations; Elsevier EMBASE; EBSCO; Worldcat; Thomson Reuters Links Journal Title List.

Journal archiving and digital preservation: Portico






Role of Topotecan in Non-Small Cell Lung Cancer: A Review of Literature
Topotecan (TPT), a chemotherapeutic agent, is a topoisomerase-I inhibitor. Topoisomerase-I is a nuclear enzyme that relieves torsion strain in DNA by opening single strand breaks which helps in DNA replication. TPT inhibits this enzyme, thus preventing DNA replication and causes cell death. TPT has demonstrated to have broad spectrum of antitumor activity in tumors like cervical, ovarian, endometrial and small cell lung cancers (SCLCs). Full Text

The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams
The aim of the study was to clarify the effect of p53 status of tumor cells on radiosensitivity of solid tumors following accelerated carbon-ion beam irradiation compared with γ-rays or reactor neutron beams, referring to the response of intratumor quiescent (Q) cells. Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/mp53) or with neo vector (SAS/neo) were injected subcutaneously into hind legs of nude mice. Full Text

Image of the Issue

Primary Non-Hodgkin’s Lymphoma of the Spine: A Case Report and Literature Review
Primary non-Hodgkin’s lymphoma (NHL) of the spine is a rare form of extranodal lymphoma. This entity constitutes a diagnostic challenge due to its mimicking of other spinal diseases and the difficulty in establishing a tissue diagnosis. In fact, core biopsy can be inconclusive, oftentimes requiring surgical biopsy. Definitive evidence is lacking regarding the treatment of choice. As a result, the prognosis remains unfavorable. We present the case of an adult female who presented with back pain and was found to have a spinal NHL. Full Text

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Vol. 6, No. 5, Oct 2015

Table of Contents


Role of Topotecan in Non-Small Cell Lung Cancer: A Review of Literature Abstract HTML PDF
Adarsh Vennepureddy, Jean-Paul Atallah, Terenig Terjanian 429-436

Original Article

FCGRs Polymorphisms and Response to Trastuzumab in Patients With HER2-Positive Breast Cancer: Far From Predictive Value? Abstract HTML PDF
Andrea Botticelli, Federica Mazzuca, Marina Borro, Eva Mazzotti, Marco La Torre, Adriana Bonifacino, Francesca Romana Ciabatta, Giovanna Gentile, Chiara Maddalena, Maurizio Simmaco, Paolo Marchetti 437-440
Initial Surgery in Tailoring Treatment for Children With Stage II and III Wilms’ Tumor: An Experience From Resource Challenged Settings Abstract HTML PDF
Ossama M. Zakaria, Emad N. Hokkam, Karam Al Sayem, Mohamed Yasser I. Daoud, Hazem M. Zakaria, Fouad Sedky, Seba H. Graiz, Saleh A. Moussa, Hamed A. Al Wadaani 441-445
Utility of SOX2 and Livin Co-Expression in the Prognosis of Bladder Cancer With Bilharzial and Non-Bilharzial Bladder Status Abstract HTML PDF
Mariana Fathy Gayyed, Ehab Rifat Tawfiek 446-455

Case Report

Diffuse Gastric Cancer During Pregnancy: Report of a Rare Association Abstract HTML PDF
Orivaldo Alves Barbosa, Anna Dorotheia Bezerra de Souza, Mayna Raphaela de Carvalho Moura, Elson Jose de Almeida Junior, Joao Paulo Uchoa Fontenele, Fabio de Figuereido Chaves, Jose Walter Correia 456-458
Primary Non-Hodgkin’s Lymphoma of the Spine: A Case Report and Literature Review Abstract HTML PDF
Elias Moussaly, Bassel Nazha, Mazen Zaarour, Jean Paul Atallah 459-463
Spontaneous Tumor Lysis Syndrome in Small-Cell Lung Cancer: A Rare Complication Abstract HTML PDF
Chanudi Weerasinghe, Mazen Zaarour, Sami Arnaout, Gwenalyn Garcia, Meekoo Dhar 464-471
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World Journal of Oncology, bimonthly, ISSN 1920-4531 (print), 1920-454X (online), published by Elmer Press Inc.     
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