World Journal of Oncology


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Kazuaki Takabe, MD, PhD, FACS
Professor, Alfiero Foundation Chair, and Clinical Chief of Breast Surgery in Department of Surgical Oncology at Roswell Park Comprehensive Cancer Center in Buffalo, New York, USA
Professor of Surgery with Tenure in Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, USA

ISSN-print: 1920-4531 | ISSN-online: 1920-454X | Open Access | Bimonthly | Aims and Scope

Indexed and covered: PubMed, PubMed Central, Scopus, Elsevier Embase, Web of Science, Chemical Abstract (CA), EBSCO, Worldcat, Google, Google Scholar.

JCR Impact Factor (JIF 2022): 5.2. Q1, 47/317 (85%) Oncology (Rank by Journal Citation Indicator)

CiteScore (2023): 6.1; Journal Rank: 126/404 (Oncology)

Journal archiving and digital preservation:


  • DNA Damage-Induced Apoptosis Suppressor Triggers Progression and Stemness of Glioma by Enhancing Lymphoid Enhancer-Binding Factor 1 Expression

    DNA damage-induced apoptosis suppressor (DDIAS) has recently been discovered to induce cancer progression, but its functions and mechanisms in glioma have not been well studied. In this study, DDIAS expression in glioma tissues was analyzed by the Gene Expression Profiling Interactive Analysis server (GEPIA) and the Gene Expression database of Normal and Tumor tissue 2 (GENT2) databases.

  • Oxygen and Iron Availability Shapes Metabolic Adaptations of Cancer Cells

    The dynamic changes between glycolysis and oxidative phosphorylation (OXPHOS) for adenosine triphosphate (ATP) output, along with glucose, glutamine, and fatty acid utilization, etc., lead to the maintenance and selection of growth advantageous to tumor cell subgroups in an environment of iron starvation and hypoxia.

  • Circadian Clock REV-ERBs Agonist SR9009 Induces Synergistic Antitumor Activity in Multiple Myeloma by Suppressing Glucose-Regulated Protein 78-Dependent Autophagy and Lipogenesis

    Proteasome inhibitors, such as bortezomib, have demonstrated efficacy in the therapeutic management of multiple myeloma (MM). However, it is important to note that these inhibitors also elicit endoplasmic reticulum stress.

  • Folfirinox vs. Gemcitabine + Nab-Paclitaxel as the First-Line Treatment for Pancreatic Cancer: A Systematic Review and Meta-Analysis

    The efficacy and safety of Folfirinox (FFX) or gemcitabine + nab-paclitaxel (GnP) to be used as the first-line drugs for pancreatic cancer (PC) is yet to be established. We conducted an analysis of retrospective studies to assess the efficacy and safety of these two regimens by comparing their survival and safety outcomes in patients with PC.

  • Update on Radiotherapy Changes of Nasopharyngeal Carcinoma Tumor Microenvironment

    The utilization of radiotherapy (RT) serves as the principal approach for managing nasopharyngeal carcinoma (NPC). Consequently, it is imperative to investigate the correlation between the radiation microenvironment and radiation resistance in NPC.







Pigs: Large Animal Preclinical Cancer Models
Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. Full Text

Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer resistant to current therapies, including oxaliplatin (Oxa). Growing evidence supports the ability of cancers to harness sphingolipid metabolism for survival. Full Text

Key Clinical Image

Synchronous Bilateral Breast Cancer With Discordant Receptor Status: Treating One Patient but Two Diseases
The expression of hormone receptors (estrogen and progesterone) and human epidermal growth factor receptor-2 (HER2) has been used for both therapeutic and prognostic purposes in the management of breast cancer. The presence of a discordant receptor status complicates the approach to treatment in patients with synchronous bilateral breast cancer. Full Text

Current Issue


Vol. 15, No. 3, Jun 2024

Table of Contents


Potential Therapeutic Role of Respiratory Muscle Training in Dyspnea Management of Cancer Survivors: A Narrative Review Abstract HTML PDF Suppl1
Baruch Vainshelboim, Sagar D. Sardesai, Dharini Bhammar 337-347
Multiple Myeloma: A Review of the Literature and a Case Report Highlighting the Immunocompromised State of Myeloma Patients Abstract HTML PDF
Brandon Nightingale, Megan Decker, Robert Ryan, Karolina Kaczmarczyk, Parul Jandir, Trupti Waykole, Remi Ashkar, Gabriella Harmon, Ajay Mathur, Michael Levitt 348-354
Intercontinental Comparison of Immunohistochemical Subtypes Among Individuals With Breast Cancer in South-East Asia and South America: A Scoping Systematic Review and Meta-Analysis of Observational Studies Abstract HTML PDF Suppl1
Dedy Hermansyah, Naufal Nandita Firsty, Ruth Hasian Nami Siagian, Najwa Nandita Dwinda 355-371
Comprehensive Insights Into Renal Perivascular Epithelioid Cell Neoplasms: From Molecular Mechanisms to Clinical Practice Abstract HTML PDF
Bao Nan Dong, Hui Zhan, Ting Luan, Jian Song Wang 372-381
The Potential Role of Virus Infection in the Progression of Thyroid Cancer Abstract HTML PDF
Yong Ke Wu, Tian Tian Jiang, Yuan Hao Su, Lin Mei, Ting Kai Sun, Yun Hao Li, Zhi Dong Wang, Yuan Yuan Ji 382-393
Diagnosis and Management of Desmoid Fibromatosis of the Breast Abstract HTML PDF
Aeryn Kangas-Dick, Muhammad Ali, Mariola Poss, Thaer Khoury, Kazuaki Takabe 394-404

Original Article

Therapeutic Outcome of Multidisciplinary Treatment in Unresectable Biliary Tract Cancer: A Multicenter Retrospective Analysis Abstract HTML PDF
Fumi Harada, Kentaro Miyake, Ryusei Matsuyama, Kazunori Furuta, Mitsuhiro Kida, Shinichi Ohkawa, Jun-ichi Tanaka, Takeshi Asakura, Kazuya Sugimori, Yoshiaki Kawaguchi, Tetsuya Mine, Kazumi Kubota, Hiroshi Shimada, Itaru Endo 405-413
Three-Dimensional-Printed Template-Guided Radioactive Seed Brachytherapy via a Submental Approach for Recurrent Base of Tongue and Floor of Mouth Cancer Abstract HTML PDF
Zhe Ji, Yu Liang Jiang, Hai Tao Sun, Bin Qiu, Mao Li, Jing Hong Fan, Jun Jie Wang 414-422
A Retrospective Study of Complications Following Pelvic and Para-Aortic Lymphadenectomy in Gynecologic Oncology Abstract HTML PDF Suppl1 Suppl2
Thitima Saemathong, Woraphot Chaowawanit 423-431
Epidemiology of Adenosquamous Carcinomas Abstract HTML PDF Suppl1 Suppl2 Suppl3
Matthew G.K. Benesch, Vicente O. Ramos-Santillan, Colin J. Rog, Erek D. Nelson, Kazuaki Takabe 432-453
Efficacy of First-Line Treatment With Pertuzumab and Trastuzumab in Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer in Routine Clinical Practice Abstract HTML PDF
Natalia Camejo, Cecilia Castillo, Dahiana Amarillo, Heber de los Santos, Gaston Samurio, Ahinara Silva-Marquez, Franco Sosa, Claudia Vera, Rocio Xavier, Guadalupe Herrera, Isabel Alonso, Gabriel Krygier 454-462
Deciphering Trends in Cancer Mortality: A Comprehensive Analysis of Brazilian Data From 1979 to 2021 With Emphasis on Breast and Prostate Cancers Abstract HTML PDF
Leonardo Pires Paredes, Marlon da Silva Brandao Rodrigues, Ralph Santos-Oliveira 463-471
Mitochondria of T Lymphocytes Promote Anti-Pulmonary Tumor Immune Response Abstract HTML PDF Suppl1
Minsuk Kim 472-481
Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans Abstract HTML PDF Suppl1 Suppl2 Suppl3 Suppl4 Suppl5 Suppl6 Suppl7 Suppl8 Suppl9 Suppl10 Suppl11
Jia Hao Zhu, Ben Jie Xu, Xiang Yi Pang, Jie Lian, Ke Gu, Sheng Jun Ji, Hai Bo Lu 482-491
Synergistic Effects of Neratinib in Combination With Palbociclib or Miransertib in Brain Cancer Cells Abstract HTML PDF
Ermira Mulliqi, Said Khelwatty, Anna Morgan, Keyoumars Ashkan, Helmout Modjtahedi 492-505

Short Communication

Definitive Radiotherapy for Stage I Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Retrospective Cohort of Unique-Dose Administration of 30 Gy in 15 Fractions and Analysis of Remission Duration Abstract HTML PDF
Atsuto Katano, Hideomi Yamashita 506-510

Case Report

Complete Pathologic Response to Gemcitabine and Oxaliplatin Chemotherapy After Prior Therapies in a Patient With Hepatocellular Carcinoma and Peritoneal Metastases Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Abstract HTML PDF
Amry Majeed, Sneha Alaparthi, Dina Halegoua-DeMarzio, Jaime Eberle-Singh, Wei Jiang, Pramila Rani Anne, Ashesh P. Shah, Wilbur B. Bowne, Daniel Lin 511-520
Inflammatory Myofibroblastic Tumor of the Sciatic Nerve Mimicking Lumbar Disc Herniation: A Diagnostic Challenge Abstract HTML PDF
Chang Jun Chen, Jun Feng Yin, Jing Wen Zhao, Xin Zhao, Hao Xuan Zhang, Meng Chen, Da Yong Peng 521-525

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World Journal of Oncology, bimonthly, ISSN 1920-4531 (print), 1920-454X (online), published by Elmer Press Inc.                     
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