EGFR Mutation Detection and Its Association With Clinicopathological Characters of Lung Cancer Patients

Priyanka Gaur, Sandeep Bhattacharya, Surya Kant, R.A.S. Kushwaha, Gaurav Singh, Sarika Pandey


Background: Lung cancer is the most common type of cancer worldwide with an estimation of 1.82 million new cancer cases diagnosed; and it is the leading cause of cancer-related deaths. Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase identified as being highly expressed in cancer cells including lung cancers. The aim of the study is to determine the EGFR mutation status in non-small cell lung cancer (NSCLC) patients to investigate the association between the EGFR mutation status and clinicopathological characters of patients.

Methods: The tissue samples of the lung cancer patients were collected bronchoscopically. The EGFR mutations of 70 NSCLC patients were determined by the immunohistochemistry (IHC).

Results: EGFR mutations were present in 24 cases (34.29%), including 19 (79.13%) cases of exon 19 and five (20.83%) cases of exon 21 mutation. EGFR mutations were frequently associated with adenocarcinoma and non-smoker. Statistically significant association of EGFRmutations with adenocarcinoma subtypes and non-smokers was found (P < 0.05); and no significant association of EGFR mutation with the age of the patient (P = 0.4647) and the stage (P = 0.4578) of the tumor was found. When we compared between these two mutations, no significant association with age (P=0.614) and smoking status (P=0.127) was found in this study.

Conclusions: EGFR mutations were significantly associated with female sex, non-smoker and adenocarcinoma subtypes. The analysis of EGFR mutation by the IHC method is a potentially useful tool to guide clinicians for personalized treatment of NSCLC patients of adenocarcinoma subtype.

World J Oncol. 2018;9(5-6):151-155



Lung cancer; EGFR; Immunohistochemistry; Non-small cell lung carcinomas

Full Text: HTML PDF

Browse  Journals  


Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






World Journal of Oncology, bimonthly, ISSN 1920-4531 (print), 1920-454X (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.