Dural Marginal Zone Lymphoma in a Patient With a Hepatitis C Virus Infection

Matthew T. Villaume, Dilan Patel, Christine Lopez, Vivek Patel, Pauleatha Diggs, Hannah Harmsen, Mary Ann Thompson, David Morgan


Primary dural marginal zone lymphomas (MZLs) are exceptionally rare, with fewer than 100 cases reported to date. While the association between hepatitis C virus (HCV) infection and lymphoma is well established, it is unclear if this association extends to all anatomic sites. Here we report a case of dural MZL in a 61-year-old woman with an HCV infection. To our knowledge, this is the first report of a dural MZL associated with an HCV infection in an immunocompetent patient and was successfully treated with radiotherapy and rituximab. As such, future cases of primary MZL found in the dura should prompt consideration of co-infection with microbials such as HCV and upfront treatment with anti-virals should be considered.

World J Oncol. 2020;11(3):122-125
doi: https://doi.org/10.14740/wjon1285


Hepatitis C virus; Marginal zone lymphoma; Dura

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