Early Recognition of Immune Reconstitution Inflammatory Syndrome Leads to Avoidance of Endotracheal Intubation

Johan Barretto, Baldeep Wirk

Abstract


Immune reconstitution inflammatory syndrome occurs in patients with rapidly recovering immune systems in response to antigens (viable pathogens, nonviable pathogen debris, host antigens or tumor antigens). The acronym IRIS, Greek for spectrum of color, is often used for immune reconstitution inflammatory response syndrome and reflects the wide spectrum of clinical manifestations associated with this entity. This is a case report of an acute myelogenous leukemia patient with neutropenia after cytotoxic chemotherapy who developed severe dyspnea and new pulmonary infiltrates temporally associated with rapid neutrophil recovery. The incidence, pathogenesis, clinical presentation and therapy of IRIS will be discussed in this article. There should be an increased awareness of the many clinical manifestations of IRIS in hematologic malignancy patients with rapid neutrophil recovery after cytotoxic chemotherapy, in order to allow prompt institution of corticosteroids which could be life saving.




doi: http://dx.doi.org/10.4021/wjon527w

Keywords


Immune reconstitution inflammatory syndrome; IRIS; Neutrophil recovery; Chemotherapy

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

World Journal of Oncology, bimonthly, ISSN 1920-4531 (print), 1920-454X (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.wjon.org   editorial contact: editor@wjon.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.