Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy

Daniel Brungs, Victor Sze, Louise Emmett, Richard J. Epstein


The blood-brain barrier is traditionally regarded as an insurmountable obstacle to the effective drug therapy of brain metastases from solid tumors. Here we describe a striking case of complete radiologic response to chemotherapy, and propose that the critical success factors include the large tumor size, HER2-positivity, and concomitant use of trastuzumab.

World J Oncol. 2013;4(2):122-125


Cerebral metastasis; Blood-brain barrier; Cancer chemotherapy; Breast neoplasms

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