Effect of MTHFR Polymorphisms on Gastrointestinal Cancer Risk in Italy

Federica Mazzuca, Marina Borro, Andrea Botticelli, Laura Aimati, Giovanna Gentile, Carlo Capalbo, Chiara Maddalena, Eva Mazzotti, Maurizio Simmaco, Paolo Marchetti

Abstract


Background: The aim of the study was to assess the association of single nucleotide polymorphisms (SNPs) C677T and A1298C in the methylenetetrahydrofolate reductase gene with colorectal, esophageal/gastric and pancreatic cancer in a cohort of Italian patients.

Methods: A total of 790 cancer patients and 202 healthy controls were genotyped and distributions in genotype and allele frequencies were compared by Chi-squared analysis and logistic regression analysis.

Results: According to most of previous findings, we found an effect of the C677T variant, but no effect of the A1298C, in colorectal and esophageal/gastric, whereas no association was evidenced with pancreatic cancer. We found that only homozygous TT carriers of the C677T variant had an increased risk for onset of cancer.

Conclusion: This result could be related to dietary and behavioral habits of the analyzed population, which could mitigate the deleterious effect of the T allele in heterozygosity and it highlights the importance to validate genetic determinant of cancer risk in different population and geographical areas.




World J Oncol. 2015;6(4):394-397
doi: http://dx.doi.org/10.14740/wjon930w


Keywords


MTHFR; Polymorphisms; Gastrointestinal; Cancer risk; Colorectal

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