Posterior Reversible Encephalopathy Syndrome in a Bone Marrow Transplant Patient: A Complication of Immunosuppressive Drugs?

Mohammad A. Hossain, Waqas Jehangir, Qiang Nai, Naureen Jessani, Rafay Khan, Abdalla Yousif, Shuvendu Sen


Posterior reversible encephalopathy is a complex but well-recognized clinical and radiological entity associated with a variety of benign and malignant conditions including hypertensive encephalopathy, eclampsia, renal failure and immunosuppressive drugs. The pathogenesis is incompletely understood, although it seems to be related to the breakthrough of auto-regulation and endothelial dysfunction. The clinical syndromes typically involve headache, altered mental status, seizures, visual disturbance and other focal neurological signs and radiographically reversible vasogenic subcortical edema without infarction. Here, we report a case of posterior reversible encephalopathy syndrome in a patient with chronic myeloid leukemia who received allogenic bone marrow transplantation (allo-BMT) and immunosuppressive drugs.

World J Oncol. 2015;6(4):426-428


Posterior reversible encephalopathy syndrome; Tacrolimus; Chronic myeloid leukemia; Bone marrow transplantation; Immunosuppressants

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